(R)-5-(4-cyano-2-methoxycarbonylmethyl-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

Base Information

Chemical Name:(R)-5-(4-cyano-2-methoxycarbonylmethyl-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester
CAS No.:1613621-75-2
Molecular Formula:C₂₅H₂₀F₃N₅O₅
Molecular Weight:527.46
Hs Code.:

(R)-5-(4-cyano-2-methoxycarbonylmethyl-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

Synonyms:(R)-5-(4-cyano-2-methoxycarbonylmethyl-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

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Chemical Property of (R)-5-(4-cyano-2-methoxycarbonylmethyl-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

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Technology Process of (R)-5-(4-cyano-2-methoxycarbonylmethyl-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

There total 21 articles about (R)-5-(4-cyano-2-methoxycarbonylmethyl-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613621-60-5
(S)-5-(2-bromo-4-cyanophenyl)-7-methyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4] triazolo[4,3-a] pyrimidine-6-carboxylic acid methyl ester

: 77086-38-5
ketene t-butyldimethylsilyl methyl acetal

: 1613621-75-2
(R)-5-(4-cyano-2-methoxycarbonylmethyl-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

Guidance literature:: (S)-5-(2-bromo-4-cyanophenyl)-7-methyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4] triazolo[4,3-a] pyrimidine-6-carboxylic acid methyl ester; ketene t-butyldimethylsilyl methyl acetal; With zinc(II) fluoride; tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene; at 135 ℃; for 5h; Inert atmosphere; Microwave irradiation;

With trifluoroacetic acid; In methanol; at 20 ℃; for 18h;

Reference yield:

: C₃₁H₃₆F₃N₅O₅Si

: 1613621-75-2
(R)-5-(4-cyano-2-methoxycarbonylmethyl-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

Guidance literature:: With trifluoroacetic acid; In methanol; at 20 ℃; for 18h;

Reference yield:

: 1613621-86-5
(S)-4-(2-Bromo-4-carboxy-phenyl)-6-methyl-2-thioxo-1-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester

: 1613621-75-2
(R)-5-(4-cyano-2-methoxycarbonylmethyl-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 °C

1.2: 2 h / 10 - 20 °C

2.1: trichlorophosphate / N,N-dimethyl-formamide / 0 - 10 °C

2.2: 40 - 45 °C

3.1: 2,6-dimethylpyridine / dichloromethane / 0.42 h / 2 - 20 °C

3.2: 2.42 h / 7 - 20 °C

4.1: tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; zinc(II) fluoride / N,N-dimethyl-formamide; toluene / 5 h / 135 °C / Microwave irradiation; Inert atmosphere

5.1: trifluoroacetic acid / methanol / 18 h / 20 °C

With 2,6-dimethylpyridine; zinc(II) fluoride; tri-tert-butyl phosphine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; bis(dibenzylideneacetone)-palladium⁽⁰⁾; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;