{Ethoxycarbonylmethyl-[4-((2R,3R)-3-hydroxy-2-trityloxymethyl-pent-4-enyl)-benzoyl]-amino}-acetic acid ethyl ester

Base Information

Chemical Name:{Ethoxycarbonylmethyl-[4-((2R,3R)-3-hydroxy-2-trityloxymethyl-pent-4-enyl)-benzoyl]-amino}-acetic acid ethyl ester
CAS No.:329796-63-6
Molecular Formula:C₄₀H₄₃NO₇
Molecular Weight:649.784
Hs Code.:

Synonyms:{Ethoxycarbonylmethyl-[4-((2R,3R)-3-hydroxy-2-trityloxymethyl-pent-4-enyl)-benzoyl]-amino}-acetic acid ethyl ester

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Chemical Property of {Ethoxycarbonylmethyl-[4-((2R,3R)-3-hydroxy-2-trityloxymethyl-pent-4-enyl)-benzoyl]-amino}-acetic acid ethyl ester

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Technology Process of {Ethoxycarbonylmethyl-[4-((2R,3R)-3-hydroxy-2-trityloxymethyl-pent-4-enyl)-benzoyl]-amino}-acetic acid ethyl ester

There total 8 articles about {Ethoxycarbonylmethyl-[4-((2R,3R)-3-hydroxy-2-trityloxymethyl-pent-4-enyl)-benzoyl]-amino}-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6290-05-7
Diethyl iminodiacetate

: 329796-59-0
4-((2R,3R)-3-Hydroxy-2-trityloxymethyl-pent-4-enyl)-benzoic acid

: 329796-63-6
{Ethoxycarbonylmethyl-[4-((2R,3R)-3-hydroxy-2-trityloxymethyl-pent-4-enyl)-benzoyl]-amino}-acetic acid ethyl ester

Guidance literature:: 4-((2R,3R)-3-Hydroxy-2-trityloxymethyl-pent-4-enyl)-benzoic acid; With 2-chloro-1-methyl-pyridinium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 23 ℃; for 0.25h;

Diethyl iminodiacetate; In ethanol; dichloromethane; at 23 ℃; for 0.25h; Further stages.;
DOI:10.1021/ja0023377

Reference yield:

: 31419-42-8
3-(4-(ethoxycarbonyl)phenyl)propanoic acid

: 329796-63-6
{Ethoxycarbonylmethyl-[4-((2R,3R)-3-hydroxy-2-trityloxymethyl-pent-4-enyl)-benzoyl]-amino}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2-chloro-1-methylpyridinium iodide; Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.5 h / 23 °C

2.1: di-n-butylboron trifluoromethanesulfonate; i-Pr₂NEt / CH₂Cl₂ / 0.33 h / 0 °C

2.2: CH₂Cl₂ / 0.67 h / -78 - 0 °C

3.1: LiBH₄ / diethyl ether; tetrahydrofuran / 0.08 h / 0 °C

4.1: 91 percent / pyridine / CH₂Cl₂ / 2 h / 0 °C

5.1: 98 percent / LiOH; H₂O₂ / tetrahydrofuran; methanol; H₂O / 12 h / 46 °C

6.1: 2-chloro-1-methylpyridinium iodide; diisopropylethylamine / CH₂Cl₂ / 0.25 h / 23 °C

6.2: ethanol; CH₂Cl₂ / 0.25 h / 23 °C

With pyridine; dmap; lithium hydroxide; lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; 2-chloro-1-methyl-pyridinium iodide; dihydrogen peroxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/ja0023377

Reference yield:

: 76-83-5
trityl chloride

: 329796-63-6
{Ethoxycarbonylmethyl-[4-((2R,3R)-3-hydroxy-2-trityloxymethyl-pent-4-enyl)-benzoyl]-amino}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / pyridine / CH₂Cl₂ / 2 h / 0 °C

2.1: 98 percent / LiOH; H₂O₂ / tetrahydrofuran; methanol; H₂O / 12 h / 46 °C

3.1: 2-chloro-1-methylpyridinium iodide; diisopropylethylamine / CH₂Cl₂ / 0.25 h / 23 °C

3.2: ethanol; CH₂Cl₂ / 0.25 h / 23 °C

With pyridine; lithium hydroxide; 2-chloro-1-methyl-pyridinium iodide; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ja0023377