(4R,4aR)-4-(2-Diisopropylamino-ethyl)-1-ethyl-4-phenyl-octahydro-pyrido[1,2-c]pyrimidin-3-one

Base Information

Chemical Name:(4R,4aR)-4-(2-Diisopropylamino-ethyl)-1-ethyl-4-phenyl-octahydro-pyrido[1,2-c]pyrimidin-3-one
CAS No.:96914-44-2
Molecular Formula:C₂₄H₃₉N₃O
Molecular Weight:385.593
Hs Code.:

Synonyms:(4R,4aR)-4-(2-Diisopropylamino-ethyl)-1-ethyl-4-phenyl-octahydro-pyrido[1,2-c]pyrimidin-3-one

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Chemical Property of (4R,4aR)-4-(2-Diisopropylamino-ethyl)-1-ethyl-4-phenyl-octahydro-pyrido[1,2-c]pyrimidin-3-one

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Technology Process of (4R,4aR)-4-(2-Diisopropylamino-ethyl)-1-ethyl-4-phenyl-octahydro-pyrido[1,2-c]pyrimidin-3-one

There total 4 articles about (4R,4aR)-4-(2-Diisopropylamino-ethyl)-1-ethyl-4-phenyl-octahydro-pyrido[1,2-c]pyrimidin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 96914-41-9
(4R,4aR)-4-(2-Diisopropylamino-ethyl)-1-ethyl-4-phenyl-4,4a,5,6,7,8-hexahydro-pyrido[1,2-c]pyrimidin-3-one

: 96914-44-2
(4R,4aR)-4-(2-Diisopropylamino-ethyl)-1-ethyl-4-phenyl-octahydro-pyrido[1,2-c]pyrimidin-3-one

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1021/jm00147a029

Reference yield:

: 74427-45-5,74464-83-8,74464-84-9,3737-09-5
disopyramide

: 96914-44-2
(4R,4aR)-4-(2-Diisopropylamino-ethyl)-1-ethyl-4-phenyl-octahydro-pyrido[1,2-c]pyrimidin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / H₂SO₄, H₂ / 5percent PtO₂/C / H₂O / 4 h / 75 °C / 3102.9 Torr

2: CH₂Cl₂ / 20 h / Ambient temperature

3: KOH / dimethylsulfoxide / 2 h

4: 79 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

With potassium hydroxide; lithium aluminium tetrahydride; sulfuric acid; hydrogen; PtO₂/C; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jm00147a029

Reference yield:

: 107256-81-5
α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-2-piperidineacetamide

: 96914-44-2
(4R,4aR)-4-(2-Diisopropylamino-ethyl)-1-ethyl-4-phenyl-octahydro-pyrido[1,2-c]pyrimidin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 20 h / Ambient temperature

2: KOH / dimethylsulfoxide / 2 h

3: 79 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

With potassium hydroxide; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00147a029