N-(3,5-dimethoxyphenyl)-N-(4-methoxybenzyl)-4-(methylthio)thieno[3,2-d]pyrimidine-7-carboxamide

Base Information

• Chemical Name: N-(3,5-dimethoxyphenyl)-N-(4-methoxybenzyl)-4-(methylthio)thieno[3,2-d]pyrimidine-7-carboxamide
• CAS No.: 1318130-62-9
• Molecular Formula: C₂₄H₂₃N₃O₄S₂
• Molecular Weight: 481.596
• Mol file: 1318130-62-9.mol

Synonyms:N-(3,5-dimethoxyphenyl)-N-(4-methoxybenzyl)-4-(methylthio)thieno[3,2-d]pyrimidine-7-carboxamide

Chemical Property of N-(3,5-dimethoxyphenyl)-N-(4-methoxybenzyl)-4-(methylthio)thieno[3,2-d]pyrimidine-7-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3,5-dimethoxyphenyl)-N-(4-methoxybenzyl)-4-(methylthio)thieno[3,2-d]pyrimidine-7-carboxamide

There total 8 articles about N-(3,5-dimethoxyphenyl)-N-(4-methoxybenzyl)-4-(methylthio)thieno[3,2-d]pyrimidine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3,5-dimethoxyphenyl)-4-(methylthio)thieno[3,2-d]pyrimidine-7-carboxamide (1318132-97-6) + p-methoxybenzyl chloride (824-94-2) → N-(3,5-dimethoxyphenyl)-N-(4-methoxybenzyl)-4-(methylthio)thieno[3,2-d]pyrimidine-7-carboxamide (1318130-62-9)

Guidance literature:

N-(3,5-dimethoxyphenyl)-4-(methylthio)thieno[3,2-d]pyrimidine-7-carboxamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

p-methoxybenzyl chloride; With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 6h;

Reference yield:

3H-thieno[3,2-d]pyrimidin-4-one (16234-10-9) → N-(3,5-dimethoxyphenyl)-N-(4-methoxybenzyl)-4-(methylthio)thieno[3,2-d]pyrimidine-7-carboxamide (1318130-62-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: bromine; acetic acid / 10 h / 120 °C

2.1: trichlorophosphate / 3 h / 150 °C

3.1: tetrahydrofuran / 15 h / 0 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2.5 h / 120 °C

4.2: 1 h / 20 °C

5.1: ozone / chloroform; methanol / -78 - 20 °C / Inert atmosphere

6.1: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; dimethyl sulfoxide; acetone / 0 - 20 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 15 h / 20 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

8.2: 6 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate dihydrate; bromine; sodium hydride; benzotriazol-1-ol; ozone; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile; mineral oil;

Reference yield:

7-bromo-4-chlorothieno[3,2-d]pyrimidine (31169-27-4) → N-(3,5-dimethoxyphenyl)-N-(4-methoxybenzyl)-4-(methylthio)thieno[3,2-d]pyrimidine-7-carboxamide (1318130-62-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 15 h / 0 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2.5 h / 120 °C

2.2: 1 h / 20 °C

3.1: ozone / chloroform; methanol / -78 - 20 °C / Inert atmosphere

4.1: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; dimethyl sulfoxide; acetone / 0 - 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 15 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

6.2: 6 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate dihydrate; sodium hydride; benzotriazol-1-ol; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile; mineral oil;

upstream raw materials:

N-(3,5-dimethoxyphenyl)-4-(methylthio)thieno[3,2-d]pyrimidine-7-carboxamide

p-methoxybenzyl chloride

3H-thieno[3,2-d]pyrimidin-4-one

7-bromo-4-chlorothieno[3,2-d]pyrimidine