1-benzyl-4-(4-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridinium chloride

Base Information

Chemical Name:1-benzyl-4-(4-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridinium chloride
CAS No.:1370256-35-1
Molecular Formula:C₁₉H₁₈F₃N*ClH
Molecular Weight:353.815
Hs Code.:

Synonyms:1-benzyl-4-(4-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridinium chloride

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Chemical Property of 1-benzyl-4-(4-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridinium chloride

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Technology Process of 1-benzyl-4-(4-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridinium chloride

There total 3 articles about 1-benzyl-4-(4-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridinium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 58778-51-1
1-benzyl-4-(4-(trifluoromethyl)phenyl)-piperidin-4-ol

: 1370256-35-1
1-benzyl-4-(4-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridinium chloride

Guidance literature:: With hydrogenchloride; In water; for 4h; Reflux;
DOI:10.1016/j.bmcl.2012.01.122

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1370256-35-1
1-benzyl-4-(4-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridinium chloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: iodine; magnesium / tetrahydrofuran / Inert atmosphere; Reflux

1.2: 3 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: hydrogenchloride / water / 4 h / Reflux

With hydrogenchloride; iodine; magnesium; In tetrahydrofuran; water; 1.1: Grignard reaction / 1.2: Grignard reaction;
DOI:10.1016/j.bmcl.2012.01.122

Reference yield:

: 402-43-7
p-trifluoromethylphenyl bromide

: 1370256-35-1
1-benzyl-4-(4-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridinium chloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: iodine; magnesium / tetrahydrofuran / Inert atmosphere; Reflux

1.2: 3 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: hydrogenchloride / water / 4 h / Reflux

With hydrogenchloride; iodine; magnesium; In tetrahydrofuran; water; 1.1: Grignard reaction / 1.2: Grignard reaction;
DOI:10.1016/j.bmcl.2012.01.122