4-Benzyl-5-(2-tetrahydropyranyloxy)-7-<3-oxo-7-(2-tetrahydropyranyloxy)-2-oxa-6-bicyclo<3.3.0>octyl>-6-heptennitril

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Chemical Name:4-Benzyl-5-(2-tetrahydropyranyloxy)-7-<3-oxo-7-(2-tetrahydropyranyloxy)-2-oxa-6-bicyclo<3.3.0>octyl>-6-heptennitril
CAS No.:81266-82-2
Molecular Formula:C₃₁H₄₁NO₆
Molecular Weight:523.67
Hs Code.:

Synonyms:4-Benzyl-5-(2-tetrahydropyranyloxy)-7-<3-oxo-7-(2-tetrahydropyranyloxy)-2-oxa-6-bicyclo<3.3.0>octyl>-6-heptennitril

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Chemical Property of 4-Benzyl-5-(2-tetrahydropyranyloxy)-7-<3-oxo-7-(2-tetrahydropyranyloxy)-2-oxa-6-bicyclo<3.3.0>octyl>-6-heptennitril

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Technology Process of 4-Benzyl-5-(2-tetrahydropyranyloxy)-7-<3-oxo-7-(2-tetrahydropyranyloxy)-2-oxa-6-bicyclo<3.3.0>octyl>-6-heptennitril

There total 6 articles about 4-Benzyl-5-(2-tetrahydropyranyloxy)-7-<3-oxo-7-(2-tetrahydropyranyloxy)-2-oxa-6-bicyclo<3.3.0>octyl>-6-heptennitril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 81266-80-0
7-Hydroxy-6-(4-benzyl-6-cyan-3-hydroxy-1-hexenyl)-2-oxabicyclo<3.3.0>octan-3-on

: 81266-82-2
4-Benzyl-5-(2-tetrahydropyranyloxy)-7-<3-oxo-7-(2-tetrahydropyranyloxy)-2-oxa-6-bicyclo<3.3.0>octyl>-6-heptennitril

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; at 20 ℃; for 2h;
DOI:10.1002/jlac.198219820116

Reference yield:

: 81266-69-5
2-Benzyl-4-cyano-butyric acid methyl ester

: 81266-82-2
4-Benzyl-5-(2-tetrahydropyranyloxy)-7-<3-oxo-7-(2-tetrahydropyranyloxy)-2-oxa-6-bicyclo<3.3.0>octyl>-6-heptennitril

Guidance literature:: Multi-step reaction with 5 steps

1: 1) 1,6 M BuLi / 1) THF, hexane, -78 deg C, 2) 7h, -78 deg C, 2h, 20 deg C

2: 1) 2,2 M BuLi / 1) THF, hexane, 2) 1,2-dimethoxyethane, 1h, 25 deg C

3: 98 percent / ZnCl₂, NaBH₄, / 1,2-dimethoxy-ethane / 1) 1,5 h, -20 deg C, 2) 1,5 h, 0 deg C, 3) 1,5 h, 20 deg C

4: 72 percent / K₂CO₃ / ethanol / 1.5 h / 25 °C

5: 90 percent / 2percent 4-toluoene sulfonic acid / CH₂Cl₂; tetrahydrofuran / 2 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; potassium carbonate; toluene-4-sulfonic acid; zinc(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane;
DOI:10.1002/jlac.198219820116

Reference yield:

: 81266-72-0
4-Benzyl-6-dimethoxyphosphoryl-5-oxohexannitril

: 81266-82-2
4-Benzyl-5-(2-tetrahydropyranyloxy)-7-<3-oxo-7-(2-tetrahydropyranyloxy)-2-oxa-6-bicyclo<3.3.0>octyl>-6-heptennitril

Guidance literature:: Multi-step reaction with 4 steps

1: 1) 2,2 M BuLi / 1) THF, hexane, 2) 1,2-dimethoxyethane, 1h, 25 deg C

2: 98 percent / ZnCl₂, NaBH₄, / 1,2-dimethoxy-ethane / 1) 1,5 h, -20 deg C, 2) 1,5 h, 0 deg C, 3) 1,5 h, 20 deg C

3: 72 percent / K₂CO₃ / ethanol / 1.5 h / 25 °C

4: 90 percent / 2percent 4-toluoene sulfonic acid / CH₂Cl₂; tetrahydrofuran / 2 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; potassium carbonate; toluene-4-sulfonic acid; zinc(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane;
DOI:10.1002/jlac.198219820116