(E)-N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-3-(thiophen-2-yl)acrylamide

Base Information

Chemical Name:(E)-N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-3-(thiophen-2-yl)acrylamide
CAS No.:1333163-18-0
Molecular Formula:C₂₁H₁₅ClN₄OS
Molecular Weight:406.895
Hs Code.:

Synonyms:(E)-N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-3-(thiophen-2-yl)acrylamide

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Chemical Property of (E)-N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-3-(thiophen-2-yl)acrylamide

Chemical Property:

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Technology Process of (E)-N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-3-(thiophen-2-yl)acrylamide

There total 6 articles about (E)-N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-3-(thiophen-2-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28424-61-5,73186-06-8,119924-24-2
(2E)-3-(2-thiophenyl)-2-propenoyl chloride

: 153436-71-6
6-amino-4-[(3-chlorophenyl)amino]quinazoline

: 1333163-18-0
(E)-N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-3-(thiophen-2-yl)acrylamide

Guidance literature:: With potassium carbonate; In ethyl acetate; at 0 ℃; Reflux;
DOI:10.1016/j.bmc.2011.06.044

Reference yield:

: 15690-25-2,51019-83-1,1124-65-8
3-(2-thienyl)acrylic acid

: 153436-71-6
6-amino-4-[(3-chlorophenyl)amino]quinazoline

: 1333163-18-0
(E)-N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-3-(thiophen-2-yl)acrylamide

Guidance literature:: With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃; for 6h;
DOI:10.1016/j.bmc.2013.06.070

Reference yield:

: 17420-30-3
5-nitroanthranilonitrile

: 1333163-18-0
(E)-N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-3-(thiophen-2-yl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 2 h / Reflux

2: acetic acid / 2 h / Reflux

3: iron; acetic acid / ethanol; water / 70 - 80 °C

4: potassium carbonate / ethyl acetate / 0 °C / Reflux

With iron; potassium carbonate; acetic acid; In ethanol; water; ethyl acetate;
DOI:10.1016/j.bmc.2011.06.044