N¹-(4-methoxyphenyl)-N³-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluoro-butoxy)phenyl)-butan-2-yl)malonamide

Base Information

• Chemical Name: N¹-(4-methoxyphenyl)-N³-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluoro-butoxy)phenyl)-butan-2-yl)malonamide
• CAS No.: 1441057-92-6
• Molecular Formula: C₃₁H₃₀F₆N₂O₅
• Molecular Weight: 624.58

Synonyms:N¹-(4-methoxyphenyl)-N³-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluoro-butoxy)phenyl)-butan-2-yl)malonamide

Chemical Property of N¹-(4-methoxyphenyl)-N³-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluoro-butoxy)phenyl)-butan-2-yl)malonamide

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Technology Process of N¹-(4-methoxyphenyl)-N³-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluoro-butoxy)phenyl)-butan-2-yl)malonamide

There total 12 articles about N¹-(4-methoxyphenyl)-N³-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluoro-butoxy)phenyl)-butan-2-yl)malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H10ClNO3 (1441057-94-8) + 3-amino-4,4,4-trifluoro-1-p-tolyl-3-(4-(4,4,4-trifluorobutoxy)phenyl)-butan-1-one (1441057-81-3) → N1-(4-methoxyphenyl)-N3-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluoro-butoxy)phenyl)-butan-2-yl)malonamide (1441057-92-6)

Guidance literature:

C₁₀H₁₀ClNO₃; 3-amino-4,4,4-trifluoro-1-p-tolyl-3-(4-(4,4,4-trifluorobutoxy)phenyl)-butan-1-one; With pyridine; trichloroacetonitrile; In dichloromethane; at 20 ℃; Inert atmosphere;

With methanol; at 0 - 20 ℃; for 0.666667h;

Reference yield:

3-amino-4,4,4-trifluoro-1-p-tolyl-3-(4-(4,4,4-trifluorobutoxy)phenyl)-butan-1-one (1441057-81-3) + 3-((4-methoxyphenyl)amino)-3-oxopropanoic acid (61916-60-7) → N1-(4-methoxyphenyl)-N3-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluoro-butoxy)phenyl)-butan-2-yl)malonamide (1441057-92-6)

Guidance literature:

With pyridine; trichloroacetonitrile; triphenylphosphine; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.jmedchem.1c01356

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → N1-(4-methoxyphenyl)-N3-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluoro-butoxy)phenyl)-butan-2-yl)malonamide (1441057-92-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere

2.1: cesium fluoride / 1,2-dimethoxyethane / 16 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 3.5 h / 0 - 20 °C

4.1: dimethyl sulfoxide / 160 °C / Microwave irradiation

5.1: ammonium hydroxide / dimethyl sulfoxide; water / 48 h / Sealed tube

6.1: pyridine; trichloroacetonitrile / dichloromethane / 20 °C / Inert atmosphere

6.2: 0.67 h / 0 - 20 °C

With pyridine; ammonium hydroxide; di-isopropyl azodicarboxylate; Dess-Martin periodane; trichloroacetonitrile; triphenylphosphine; cesium fluoride; In 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide;

upstream raw materials:

4-(4,4,4-trifluorobutoxy)benzaldehyde

4-hydroxy-benzaldehyde

2,2,2-trifluoro-1-(4-(4,4,4-trifluoro-butoxy)phenyl)ethanol

2,2,2-trifluoro-1-(4-(4,4,4-trifluoro-butoxy)phenyl)ethanone

Downstream raw materials:

N-(4-methoxyphenyl)-2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoro-methyl)-1,2,5,6-tetrahydropyridine-3-carboxamide

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