3-((4-oxo-8-(3-(2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)propyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid hydrochloride

Base Information

Chemical Name:3-((4-oxo-8-(3-(2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)propyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid hydrochloride
CAS No.:1352949-88-2
Molecular Formula:C₃₄H₃₆N₄O₄*ClH
Molecular Weight:601.145
Hs Code.:

Synonyms:3-((4-oxo-8-(3-(2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)propyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid hydrochloride

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Chemical Property of 3-((4-oxo-8-(3-(2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)propyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid hydrochloride

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Technology Process of 3-((4-oxo-8-(3-(2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)propyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid hydrochloride

There total 8 articles about 3-((4-oxo-8-(3-(2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)propyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 3-((4-oxo-8-(3-(2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)propyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid formate

: 1352949-88-2
3-((4-oxo-8-(3-(2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)propyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane;

Reference yield:

: 1021-25-6
1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one

: 1352949-88-2
3-((4-oxo-8-(3-(2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)propyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / dichloromethane / 16 h / 0 - 20 °C

2: sodium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 16 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 2 h

4: potassium carbonate; sodium iodide / butanone / 4 h / 78 °C

5: 20 h / 20 °C

6: hydrogenchloride / 1,4-dioxane

With pyridine; hydrogenchloride; hydrogen; sodium hexamethyldisilazane; potassium carbonate; sodium iodide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; butanone;

Reference yield:

: 1352948-13-0
benzyl 3-(3-(tert-butoxycarbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

: 1352949-88-2
3-((4-oxo-8-(3-(2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)propyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

2: potassium carbonate; sodium iodide / butanone / 4 h / 78 °C

3: 20 h / 20 °C

4: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; hydrogen; potassium carbonate; sodium iodide; palladium 10% on activated carbon; In 1,4-dioxane; methanol; butanone;