2,4-dichloro-7-(4-methoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine

Base Information

• Chemical Name: 2,4-dichloro-7-(4-methoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine
• CAS No.: 1255939-53-7
• Molecular Formula: C₁₄H₁₁Cl₂N₃O
• Molecular Weight: 308.167
• Mol file: 1255939-53-7.mol

Synonyms:2,4-dichloro-7-(4-methoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property of 2,4-dichloro-7-(4-methoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property:

Purity/Quality:

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Technology Process of 2,4-dichloro-7-(4-methoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine

There total 1 articles about 2,4-dichloro-7-(4-methoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (90213-66-4) + p-methoxybenzyl chloride (824-94-2) → 2,4-dichloro-7-(4-methoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine (1255939-53-7)

Guidance literature:

2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

p-methoxybenzyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.08.016

Reference yield: 85.0%

2,4-dichloro-7-(4-methoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine (1255939-53-7) + 2-(tributylstannyl)furan (118486-94-5) → 2-chloro-4-(2-furyl)-7-(4-methoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine (1255939-55-9)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; trifuran-2-yl-phosphane; In N,N-dimethyl-formamide; at 50 ℃; for 8h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.08.016

Reference yield: 54.7%

2,4-dichloro-7-(4-methoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine (1255939-53-7) + 2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline tetrahydrochloride → 4-chloro-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-7-(4-methoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Guidance literature:

With 2,2,2-trifluoroethanol; trifluoroacetic acid; In 2-methoxy-ethanol; at 110 ℃; for 72h;

upstream raw materials:

2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

p-methoxybenzyl chloride

Downstream raw materials:

2-chloro-4-(2-furyl)-7-(4-methoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine