3-acetyl-1-<(benzyloxy)methyl>-3'-methylspiro-2,2',5(3'H)-trione

Base Information

Chemical Name:3-acetyl-1-<(benzyloxy)methyl>-3'-methylspiro-2,2',5(3'H)-trione
CAS No.:107583-27-7
Molecular Formula:C₂₁H₂₀N₄O₅
Molecular Weight:408.414
Hs Code.:

3-acetyl-1-<(benzyloxy)methyl>-3'-methylspiro<imidazolidine-4,4'(1'H)-quinazoline>-2,2',5(3'H)-trione

Synonyms:3-acetyl-1-<(benzyloxy)methyl>-3'-methylspiro-2,2',5(3'H)-trione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-acetyl-1-<(benzyloxy)methyl>-3'-methylspiro-2,2',5(3'H)-trione

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Technology Process of 3-acetyl-1-<(benzyloxy)methyl>-3'-methylspiro-2,2',5(3'H)-trione

There total 6 articles about 3-acetyl-1-<(benzyloxy)methyl>-3'-methylspiro-2,2',5(3'H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 107583-27-7
3-acetyl-1-<(benzyloxy)methyl>-3'-methylspiro-2,2',5(3'H)-trione

Guidance literature:

Reference yield:

: 42366-35-8,1769-41-1
hydroxyimino-N-phenylacetamide

: 107583-27-7
3-acetyl-1-<(benzyloxy)methyl>-3'-methylspiro-2,2',5(3'H)-trione

Guidance literature:: Multi-step reaction with 5 steps

1: conc. H₂SO₄ / Heating

2: Et₃N / dimethylformamide / 1 h / 0 °C

3: 1.) Et₃N, 2.) 10percent aq. HCl / 1.) THF, RT, 3 h, 2.) THF, 80 deg C, 3 h

4: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h

5: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h

With hydrogenchloride; sulfuric acid; sodium hydride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00089a021

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 107583-27-7
3-acetyl-1-<(benzyloxy)methyl>-3'-methylspiro-2,2',5(3'H)-trione

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / dimethylformamide / 1 h / 0 °C

2: 1.) Et₃N, 2.) 10percent aq. HCl / 1.) THF, RT, 3 h, 2.) THF, 80 deg C, 3 h

3: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h

4: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h

With hydrogenchloride; sodium hydride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00089a021