Technology Process of (2S,3S)-6-(4-methoxybenzyloxy)hexane-1,2,3-triol
There total 8 articles about (2S,3S)-6-(4-methoxybenzyloxy)hexane-1,2,3-triol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methanesulfonamide; AD-mix α;
In
water; tert-butyl alcohol;
at 0 ℃;
for 24h;
DOI:10.1002/asia.201100429
- Guidance literature:
-
With
methanesulfonamide; potassium carbonate; potassium hexacyanoferrate(III);
(3a,9R,3'''a,4'"b,9'"R)-9,9'-[1,4-phthalazinediylbis(oxy)]bis[6'-(methyloxy)-10,11-dihydrocinchonan]; osmium(VIII) oxide;
In
water; toluene; tert-butyl alcohol;
at 0 ℃;
for 18h;
Title compound not separated from byproducts;
DOI:10.1021/jo0485381
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 71 percent / pyridinium chlorochromate; sodium acetate; celite / CH2Cl2 / 6 h / 20 °C
2: 80 percent / benzene / 4 h / Heating
3: 80 percent / DIBAL-H / CH2Cl2 / 1 h / 20 °C
4: potassium ferricyanide; methanesulfonamide; K2CO3 / osmium tetraoxide; 1,4-bis(dihydroquinin-9-O-yl)phthalazine / 2-methyl-propan-2-ol; H2O; toluene / 18 h / 0 °C
With
methanesulfonamide; Celite; sodium acetate; diisobutylaluminium hydride; potassium carbonate; pyridinium chlorochromate; potassium hexacyanoferrate(III);
(3a,9R,3'''a,4'"b,9'"R)-9,9'-[1,4-phthalazinediylbis(oxy)]bis[6'-(methyloxy)-10,11-dihydrocinchonan]; osmium(VIII) oxide;
In
dichloromethane; water; toluene; tert-butyl alcohol; benzene;
2: Wittig reaction / 4: Sharpless asymmetric dihydroxylation;
DOI:10.1021/jo0485381
