4-hydrazino-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine

Base Information

• Chemical Name: 4-hydrazino-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine
• CAS No.: 109890-49-5
• Molecular Formula: C₁₅H₁₂F₃N₅S
• Molecular Weight: 351.355
• Mol file: 109890-49-5.mol

Synonyms:4-hydrazino-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine

Chemical Property of 4-hydrazino-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-hydrazino-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine

There total 3 articles about 4-hydrazino-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-amino-6-<<3-(trifluoromethyl)phenyl>thio>-4-quinazolinethiol (109890-45-1) → 4-hydrazino-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine (109890-49-5)

Guidance literature:

With hydrazine; In pyridine; Ambient temperature;

DOI:10.1021/jm00394a038

Reference yield:

2-amino-6-<<3-(trifluoromethyl)phenyl>thio>-4(3H)-quinazolinone (109890-44-0) → 4-hydrazino-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine (109890-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / P₂S₅ / pyridine / 22 h / 80 °C

2: 73 percent / hydrazine / pyridine / Ambient temperature

With tetraphosphorus decasulfide; hydrazine; In pyridine;

DOI:10.1021/jm00394a038

Reference yield:

6-<<3-(trifluoromethyl)phenyl>thio>-2,4-quinazolinediamine (51123-99-0) → 4-hydrazino-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine (109890-49-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 92.7 percent / 2 N aq. HCl / bis-(2-methoxy-ethyl) ether / 6 h / Heating

2: 70 percent / P₂S₅ / pyridine / 22 h / 80 °C

3: 73 percent / hydrazine / pyridine / Ambient temperature

With hydrogenchloride; tetraphosphorus decasulfide; hydrazine; In pyridine; diethylene glycol dimethyl ether;

DOI:10.1021/jm00394a038

upstream raw materials:

2-amino-6-<<3-(trifluoromethyl)phenyl>thio>-4-quinazolinethiol

2-amino-6-<<3-(trifluoromethyl)phenyl>thio>-4(3H)-quinazolinone

6-<<3-(trifluoromethyl)phenyl>thio>-2,4-quinazolinediamine