N-[1-(4-Amino-benzyl)-3,3,3-trifluoro-2-oxo-propyl]-benzamide; hydrochloride

Base Information

Chemical Name:N-[1-(4-Amino-benzyl)-3,3,3-trifluoro-2-oxo-propyl]-benzamide; hydrochloride
CAS No.:106943-05-9
Molecular Formula:C₁₇H₁₅F₃N₂O₂*ClH
Molecular Weight:372.774
Hs Code.:

Synonyms:N-[1-(4-Amino-benzyl)-3,3,3-trifluoro-2-oxo-propyl]-benzamide; hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[1-(4-Amino-benzyl)-3,3,3-trifluoro-2-oxo-propyl]-benzamide; hydrochloride

Chemical Property:

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Technology Process of N-[1-(4-Amino-benzyl)-3,3,3-trifluoro-2-oxo-propyl]-benzamide; hydrochloride

There total 6 articles about N-[1-(4-Amino-benzyl)-3,3,3-trifluoro-2-oxo-propyl]-benzamide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 106746-00-3
N-[3,3,3-Trifluoro-2-oxo-(4-nitrophenylmethyl)propyl]benzamide

: 106943-05-9
N-[1-(4-Amino-benzyl)-3,3,3-trifluoro-2-oxo-propyl]-benzamide; hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1016/S0040-4039(00)84319-1

Reference yield:

: 1991-83-9,2922-40-9,56613-61-7,949-99-5
4-nitrophenylalanine

: 106943-05-9
N-[1-(4-Amino-benzyl)-3,3,3-trifluoro-2-oxo-propyl]-benzamide; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: NaOH / diethyl ether; H₂O / pH=10-12

2: Ac₂O

3: 40 °C / under N₂

4: oxalic acid / 0.25 h / 110 - 120 °C

5: 50 percent / H₂, HCl / Pd/C / ethyl acetate

With hydrogenchloride; sodium hydroxide; hydrogen; oxalic acid; acetic anhydride; palladium on activated charcoal; In diethyl ether; water; ethyl acetate;
DOI:10.1016/S0040-4039(00)84319-1

Reference yield:

: 101468-97-7
N-benzoyl-(4'-nitro)phenylalanine

: 106943-05-9
N-[1-(4-Amino-benzyl)-3,3,3-trifluoro-2-oxo-propyl]-benzamide; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: Ac₂O

2: 40 °C / under N₂

3: oxalic acid / 0.25 h / 110 - 120 °C

4: 50 percent / H₂, HCl / Pd/C / ethyl acetate

With hydrogenchloride; hydrogen; oxalic acid; acetic anhydride; palladium on activated charcoal; In ethyl acetate;
DOI:10.1016/S0040-4039(00)84319-1