(Z)-(7R,10S,16R,19S)-10-Benzyl-19-(4-hydroxy-benzyl)-7-isobutyl-16-methyl-7,8,10,11,13,14,16,17,19,20-decahydro-5-oxa-8,11,14,17,20-pentaaza-benzocyclohenicosene-6,9,12,15,18,21-hexaone

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Chemical Name:(Z)-(7R,10S,16R,19S)-10-Benzyl-19-(4-hydroxy-benzyl)-7-isobutyl-16-methyl-7,8,10,11,13,14,16,17,19,20-decahydro-5-oxa-8,11,14,17,20-pentaaza-benzocyclohenicosene-6,9,12,15,18,21-hexaone
CAS No.:240820-24-0
Molecular Formula:C₃₈H₄₃N₅O₈
Molecular Weight:697.788
Hs Code.:

(Z)-(7R,10S,16R,19S)-10-Benzyl-19-(4-hydroxy-benzyl)-7-isobutyl-16-methyl-7,8,10,11,13,14,16,17,19,20-decahydro-5-oxa-8,11,14,17,20-pentaaza-benzocyclohenicosene-6,9,12,15,18,21-hexaone

Synonyms:(Z)-(7R,10S,16R,19S)-10-Benzyl-19-(4-hydroxy-benzyl)-7-isobutyl-16-methyl-7,8,10,11,13,14,16,17,19,20-decahydro-5-oxa-8,11,14,17,20-pentaaza-benzocyclohenicosene-6,9,12,15,18,21-hexaone

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Chemical Property of (Z)-(7R,10S,16R,19S)-10-Benzyl-19-(4-hydroxy-benzyl)-7-isobutyl-16-methyl-7,8,10,11,13,14,16,17,19,20-decahydro-5-oxa-8,11,14,17,20-pentaaza-benzocyclohenicosene-6,9,12,15,18,21-hexaone

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Technology Process of (Z)-(7R,10S,16R,19S)-10-Benzyl-19-(4-hydroxy-benzyl)-7-isobutyl-16-methyl-7,8,10,11,13,14,16,17,19,20-decahydro-5-oxa-8,11,14,17,20-pentaaza-benzocyclohenicosene-6,9,12,15,18,21-hexaone

There total 8 articles about (Z)-(7R,10S,16R,19S)-10-Benzyl-19-(4-hydroxy-benzyl)-7-isobutyl-16-methyl-7,8,10,11,13,14,16,17,19,20-decahydro-5-oxa-8,11,14,17,20-pentaaza-benzocyclohenicosene-6,9,12,15,18,21-hexaone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-2-Amino-4-methyl-pentanoic acid 2-{(Z)-2-[(S)-1-((R)-1-{[((S)-1-carboxy-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-ethylcarbamoyl)-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-vinyl}-phenyl ester

: 240820-24-0
(Z)-(7R,10S,16R,19S)-10-Benzyl-19-(4-hydroxy-benzyl)-7-isobutyl-16-methyl-7,8,10,11,13,14,16,17,19,20-decahydro-5-oxa-8,11,14,17,20-pentaaza-benzocyclohenicosene-6,9,12,15,18,21-hexaone

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In N,N-dimethyl-formamide; Yield given;
DOI:10.1016/S0960-894X(96)00526-4

Reference yield:

: 16937-99-8,53296-34-7
N-Boc-D-Leu

: 240820-24-0
(Z)-(7R,10S,16R,19S)-10-Benzyl-19-(4-hydroxy-benzyl)-7-isobutyl-16-methyl-7,8,10,11,13,14,16,17,19,20-decahydro-5-oxa-8,11,14,17,20-pentaaza-benzocyclohenicosene-6,9,12,15,18,21-hexaone

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / DCC, HOBt, DMAP

2: 100 percent / HOAc / H₂O; tetrahydrofuran

3: 83 percent / MnO₂

4: 93 percent / H₂O₂, NaClO₂ / 10 °C

5: 56 percent / DCC, HOBt, DMAP / 13 °C

6: TFA / CH₂Cl₂

7: Bop-Cl / dimethylformamide

With dmap; manganese(IV) oxide; sodium chlorite; dihydrogen peroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(96)00526-4

Reference yield:

: (R)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid 2-((Z)-3-oxo-propenyl)-phenyl ester

: 240820-24-0
(Z)-(7R,10S,16R,19S)-10-Benzyl-19-(4-hydroxy-benzyl)-7-isobutyl-16-methyl-7,8,10,11,13,14,16,17,19,20-decahydro-5-oxa-8,11,14,17,20-pentaaza-benzocyclohenicosene-6,9,12,15,18,21-hexaone

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / H₂O₂, NaClO₂ / 10 °C

2: 56 percent / DCC, HOBt, DMAP / 13 °C

3: TFA / CH₂Cl₂

4: Bop-Cl / dimethylformamide

With dmap; sodium chlorite; dihydrogen peroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(96)00526-4