(S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

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Chemical Name:(S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide
CAS No.:1584145-10-7
Molecular Formula:C₂₂H₂₉N₅O₃
Molecular Weight:411.504
Hs Code.:

Synonyms:(S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

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Chemical Property of (S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

There total 11 articles about (S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 625-05-8
3-amino-3-methylbutanoic acid

: 1584145-10-7
(S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1: chloro-trimethyl-silane / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 20 h / 0 - 20 °C

3: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

4: potassium tert-butylate / toluene / 3 h / -10 - 20 °C

5: N,N-dimethyl acetamide / 1 h / 80 °C

6: potassium acetate / N,N-dimethyl-formamide / 2 h / 90 °C

7: oxone||potassium monopersulfate triple salt / N,N-dimethyl-formamide / 3 h / 20 °C

8: N,N-dimethyl-formamide; isopropyl alcohol / 80 °C

9: hydrogenchloride / water / 5 h / 100 °C

10: N-ethyl-N,N-diisopropylamine / toluene; dichloromethane / 0.13 h / 0 °C

11: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With hydrogenchloride; chloro-trimethyl-silane; oxone||potassium monopersulfate triple salt; potassium tert-butylate; potassium acetate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

: 1584148-55-9
C₁₄H₁₉ClN₄O₂

: 20989-17-7
(2S)-2-phenylglycinol

: 1584145-10-7
(S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 1584148-41-3
methyl 3-(((benzyloxy)carbonyl)(2-methoxy-2-oxoethyl)amino)-3-methylbutanoate

: 1584145-10-7
(S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: potassium tert-butylate / toluene / 3 h / -10 - 20 °C

2: N,N-dimethyl acetamide / 1 h / 80 °C

3: potassium acetate / N,N-dimethyl-formamide / 2 h / 90 °C

4: oxone||potassium monopersulfate triple salt / N,N-dimethyl-formamide / 3 h / 20 °C

5: N,N-dimethyl-formamide; isopropyl alcohol / 80 °C

6: hydrogenchloride / water / 5 h / 100 °C

7: N-ethyl-N,N-diisopropylamine / toluene; dichloromethane / 0.13 h / 0 °C

8: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With hydrogenchloride; oxone||potassium monopersulfate triple salt; potassium tert-butylate; potassium acetate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;