(5R,7R)-[3,3,0]-1-aza-2-oxo-3-oxa-4,4-bis-(4'-t-butylphenyl)-7-(diphenylcarbamoyloxy)bicyclooctane

Base Information

Chemical Name:(5R,7R)-[3,3,0]-1-aza-2-oxo-3-oxa-4,4-bis-(4'-t-butylphenyl)-7-(diphenylcarbamoyloxy)bicyclooctane
CAS No.:1379466-23-5
Molecular Formula:C₃₉H₄₂N₂O₄
Molecular Weight:602.773
Hs Code.:

Synonyms:(5R,7R)-[3,3,0]-1-aza-2-oxo-3-oxa-4,4-bis-(4'-t-butylphenyl)-7-(diphenylcarbamoyloxy)bicyclooctane

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Chemical Property of (5R,7R)-[3,3,0]-1-aza-2-oxo-3-oxa-4,4-bis-(4'-t-butylphenyl)-7-(diphenylcarbamoyloxy)bicyclooctane

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Technology Process of (5R,7R)-[3,3,0]-1-aza-2-oxo-3-oxa-4,4-bis-(4'-t-butylphenyl)-7-(diphenylcarbamoyloxy)bicyclooctane

There total 2 articles about (5R,7R)-[3,3,0]-1-aza-2-oxo-3-oxa-4,4-bis-(4'-t-butylphenyl)-7-(diphenylcarbamoyloxy)bicyclooctane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.3%

: 1356856-79-5
(5R,7R)-[3,3,0']-1-aza-2-oxo-3-oxa-4,4-bis-(4'-t-butylphenyl)-7-hydroxybicyclooctane

: 83-01-2
diphenylcarbamic chloride

: 1379466-23-5
(5R,7R)-[3,3,0]-1-aza-2-oxo-3-oxa-4,4-bis-(4'-t-butylphenyl)-7-(diphenylcarbamoyloxy)bicyclooctane

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h; Cooling with ice;

Reference yield:

: 923985-59-5
(2R,4R)-4-hydroxyproline-N-ethyl carbamate methyl ester

: 1379466-23-5
(5R,7R)-[3,3,0]-1-aza-2-oxo-3-oxa-4,4-bis-(4'-t-butylphenyl)-7-(diphenylcarbamoyloxy)bicyclooctane

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 3 h / 5 - 10 °C / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Cooling with ice

With sodium hydride; magnesium; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;