5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]pentanenitrile

Base Information

• Chemical Name: 5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]pentanenitrile
• CAS No.: 101438-79-3
• Molecular Formula: C₁₆H₂₄N₂O₂
• Molecular Weight: 276.379
• Mol file: 101438-79-3.mol

Synonyms:5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]pentanenitrile

Chemical Property of 5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]pentanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]pentanenitrile

There total 5 articles about 5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]pentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-methylhomoveratrylamine (3490-06-0) + δ-chlorovaleronitrile (6280-87-1) → 5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]pentanenitrile (101438-79-3)

Guidance literature:

With sodium carbonate; sodium iodide; In tert-butyl alcohol; for 24h; Heating;

DOI:10.1016/j.bmc.2006.07.055

Reference yield:

N-methylhomoveratrylamine (3490-06-0) + 5-bromopentan-1-nitrile (5414-21-1) → 5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]pentanenitrile (101438-79-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 16h; Ambient temperature;

DOI:10.1248/cpb.40.2735

Reference yield:

1,2-dimethoxy-4-(2-nitro-vinyl)-benzene (4230-93-7) → 5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]pentanenitrile (101438-79-3)

Guidance literature:

Multi-step reaction with 4 steps

1: LiAlH₄; diethyl ether

2: chloral

3: LiAlH₄; THF

4: NaI; acetone / 100 °C

With tetrahydrofuran; lithium aluminium tetrahydride; diethyl ether; chloral; acetone; sodium iodide;

upstream raw materials:

N-methylhomoveratrylamine

δ-chlorovaleronitrile

5-bromopentan-1-nitrile

1,2-dimethoxy-4-(2-nitro-vinyl)-benzene

Downstream raw materials:

N-(3,4-dimethoxy-phenethyl)-N-methyl-N'-veratryl-pentanediyldiamine

2-amino-N-{5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]pentyl}benzamide

N-<2-(3,4-dimethoxyphenyl)ethyl>-N-methyl-1,5-pentanediamine