2-chloro-5-[8-(hydroxymethyl)-12-methyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-7,10-epiminocyclo-hepta[e]pyrazolo[1,5-a]pyrimidin-3-yl]phenol

Base Information

Chemical Name:2-chloro-5-[8-(hydroxymethyl)-12-methyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-7,10-epiminocyclo-hepta[e]pyrazolo[1,5-a]pyrimidin-3-yl]phenol
CAS No.:1184103-06-7
Molecular Formula:C₂₄H₂₂ClN₅O₂
Molecular Weight:447.924
Hs Code.:

Synonyms:2-chloro-5-[8-(hydroxymethyl)-12-methyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-7,10-epiminocyclo-hepta[e]pyrazolo[1,5-a]pyrimidin-3-yl]phenol

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Chemical Property of 2-chloro-5-[8-(hydroxymethyl)-12-methyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-7,10-epiminocyclo-hepta[e]pyrazolo[1,5-a]pyrimidin-3-yl]phenol

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Technology Process of 2-chloro-5-[8-(hydroxymethyl)-12-methyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-7,10-epiminocyclo-hepta[e]pyrazolo[1,5-a]pyrimidin-3-yl]phenol

There total 10 articles about 2-chloro-5-[8-(hydroxymethyl)-12-methyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-7,10-epiminocyclo-hepta[e]pyrazolo[1,5-a]pyrimidin-3-yl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1184103-03-4
methyl 3-(4-chloro-3-hydroxyphenyl)-12-methyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-7,10-epiminocyclohepta-[e]pyrazolo[1,5-a]pyrimidine-8-carboxylate

: 1184103-06-7
2-chloro-5-[8-(hydroxymethyl)-12-methyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-7,10-epiminocyclo-hepta[e]pyrazolo[1,5-a]pyrimidin-3-yl]phenol

Guidance literature:: methyl 3-(4-chloro-3-hydroxyphenyl)-12-methyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-7,10-epiminocyclohepta-[e]pyrazolo[1,5-a]pyrimidine-8-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 19h;

With water; sodium hydroxide; In tetrahydrofuran; for 1.5h;

Reference yield:

: C₁₂H₂₀N₂O₂

: 1134598-81-4,1202183-96-7
C₁₄H₁₁ClN₄O

: 1184103-06-7
2-chloro-5-[8-(hydroxymethyl)-12-methyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-7,10-epiminocyclo-hepta[e]pyrazolo[1,5-a]pyrimidin-3-yl]phenol

Guidance literature:: With acetic acid; at 80 - 100 ℃;
DOI:10.1016/j.bmcl.2009.10.058

Reference yield:

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 1184103-06-7
2-chloro-5-[8-(hydroxymethyl)-12-methyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-7,10-epiminocyclo-hepta[e]pyrazolo[1,5-a]pyrimidin-3-yl]phenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol; sodium / 2.5 h / Reflux

2.1: trichlorophosphate / 18 h / 80 °C

3.1: hydrazine hydrate / ethanol / 5 h / Reflux

4.1: pyridine hydrochloride / 2 h / 180 - 220 °C

4.2: 100 °C

5.1: acetic acid / 19 h / 100 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 19 h / 0 - 20 °C

6.2: 1.5 h

With lithium aluminium tetrahydride; ethanol; pyridine hydrochloride; sodium; hydrazine hydrate; acetic acid; trichlorophosphate; In tetrahydrofuran; ethanol;