C₁₅H₁₅IO₆

Base Information

• Chemical Name: C₁₅H₁₅IO₆
• CAS No.: 1612771-51-3
• Molecular Formula: C₁₅H₁₅IO₆
• Molecular Weight: 418.185
• Mol file: 1612771-51-3.mol

Synonyms:C₁₅H₁₅IO₆

Chemical Property of C₁₅H₁₅IO₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₅IO₆

There total 2 articles about C₁₅H₁₅IO₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C15H16O6 (1612771-50-2) → C15H15IO6 (1612771-51-3)

Guidance literature:

With N-iodo-succinimide; methanesulfonic acid; In acetic acid; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/ol501423t

Reference yield:

C11H12O4 (1612771-49-9) → C15H15IO6 (1612771-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc trifluoromethanesulfonate / tetrahydrofuran; water / 12 h / 0 °C / Inert atmosphere

2: N-iodo-succinimide; methanesulfonic acid / acetic acid / 6 h / 20 °C / Inert atmosphere

With N-iodo-succinimide; methanesulfonic acid; zinc trifluoromethanesulfonate; In tetrahydrofuran; water; acetic acid; 1: |Mukaiyama Aldol Addition;

DOI:10.1021/ol501423t

Reference yield:

C15H15IO6 (1612771-51-3) → C26H20O5Se

Guidance literature:

Multi-step reaction with 12 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; 1,2,2,6,6-pentamethylpiperidine / N,N-dimethyl-formamide / 12 h / 130 °C / Inert atmosphere

2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 4 h / 20 °C / Inert atmosphere

3.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / benzene / 5 h / 80 °C / Inert atmosphere

4.1: sodium tetrahydroborate / ethanol / 1 h / 20 °C / Inert atmosphere

5.1: toluene-4-sulfonic acid / toluene / 1 h / 80 °C / Inert atmosphere

6.1: diethylzinc; trifluoroacetic acid / dichloromethane; hexane / 0.33 h / 0 °C / Inert atmosphere

6.2: 12 h / 20 °C / Inert atmosphere

7.1: boron trichloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

8.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere

9.1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / 12 h / 100 °C / Inert atmosphere

10.1: pyridine hydrogenfluoride / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

11.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

12.1: dichloromethane / 1 h / 0 °C / Inert atmosphere

With 1,2,2,6,6-pentamethylpiperidine; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); diethylzinc; tri-n-butyl-tin hydride; boron trichloride; sodium hydride; toluene-4-sulfonic acid; pyridine hydrogenfluoride; triethylamine; trifluoroacetic acid; lithium chloride; In tetrahydrofuran; ethanol; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil; benzene; 1.1: |Heck Reaction / 3.1: |Dowd Ring Expansion / 9.1: |Stille Cross Coupling;

DOI:10.1021/ol501423t

upstream raw materials:

C₁₅H₁₆O₆

C₁₁H₁₂O₄