Ethyl-(1'R,5'R)-2-Methyl-4-<4'6'6'-trimethyl-5'-(3''-oxobut-1''-enyl)cyclohex-3'-enyl>but-2-enoat

Base Information

Chemical Name:Ethyl-(1'R,5'R)-2-Methyl-4-<4'6'6'-trimethyl-5'-(3''-oxobut-1''-enyl)cyclohex-3'-enyl>but-2-enoat
CAS No.:123393-07-7
Molecular Formula:C₂₀H₃₀O₃
Molecular Weight:318.456
Hs Code.:

Synonyms:Ethyl-(1'R,5'R)-2-Methyl-4-<4'6'6'-trimethyl-5'-(3''-oxobut-1''-enyl)cyclohex-3'-enyl>but-2-enoat

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Chemical Property of Ethyl-(1'R,5'R)-2-Methyl-4-<4'6'6'-trimethyl-5'-(3''-oxobut-1''-enyl)cyclohex-3'-enyl>but-2-enoat

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Technology Process of Ethyl-(1'R,5'R)-2-Methyl-4-<4'6'6'-trimethyl-5'-(3''-oxobut-1''-enyl)cyclohex-3'-enyl>but-2-enoat

There total 9 articles about Ethyl-(1'R,5'R)-2-Methyl-4-<4'6'6'-trimethyl-5'-(3''-oxobut-1''-enyl)cyclohex-3'-enyl>but-2-enoat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 3699-66-9
ethyl 2-diethoxyphosphorylpropionate

: 123393-06-6
(1R,5R)-5-(3'-oxobut-1'-enyl)-4,6,6-trimethylcyclohex-3-en-1-acetaldehyd

: 123393-07-7
Ethyl-(1'R,5'R)-2-Methyl-4-<4'6'6'-trimethyl-5'-(3''-oxobut-1''-enyl)cyclohex-3'-enyl>but-2-enoat

Guidance literature:: With sodium; In ethanol; dichloromethane; at 0 ℃;
DOI:10.1002/hlca.19890720120

Reference yield:

: (4R)-4-<(1,3-Dioxolan-2-yl)methyl>-1,3,3-trimethyl-1,2-epoxycyclohexan

: 123393-07-7
Ethyl-(1'R,5'R)-2-Methyl-4-<4'6'6'-trimethyl-5'-(3''-oxobut-1''-enyl)cyclohex-3'-enyl>but-2-enoat

Guidance literature:: Multi-step reaction with 8 steps

1: 43 percent / Filtrol / dioxane / 0.75 h / Ambient temperature

2: 79 percent / Cr₂O₃ / pyridine; H₂O / 14 h

3: 70 percent / 1.6 M Bu-Li / tetrahydrofuran; hexane / 0.5 h / 0 °C

4: 97 percent / EtMgBr / toluene; acetone / 4 h / Ambient temperature

5: 92 percent / NaH / tetrahydrofuran / 0.33 h / 0 °C

6: 52 percent / diethyl ether / 1 h / 0 °C

7: 98 percent / pyridinium-p-toluenesulfonate / acetone; H₂O / 16 h / Heating

8: 45 percent / Na / CH₂Cl₂; ethanol / 0 °C

With chromium(III) oxide; n-butyllithium; FILTROL; ethylmagnesium bromide; sodium; pyridinium p-toluenesulfonate; sodium hydride; In tetrahydrofuran; 1,4-dioxane; pyridine; diethyl ether; ethanol; hexane; dichloromethane; water; acetone; toluene;
DOI:10.1002/hlca.19890720120

Reference yield:

: (5R)-5-<(1,3-Dioxolan-2-yl)methyl>-2,6,6-trimethylcyclohex-2-enol

: 123393-07-7
Ethyl-(1'R,5'R)-2-Methyl-4-<4'6'6'-trimethyl-5'-(3''-oxobut-1''-enyl)cyclohex-3'-enyl>but-2-enoat

Guidance literature:: Multi-step reaction with 7 steps

1: 79 percent / Cr₂O₃ / pyridine; H₂O / 14 h

2: 70 percent / 1.6 M Bu-Li / tetrahydrofuran; hexane / 0.5 h / 0 °C

3: 97 percent / EtMgBr / toluene; acetone / 4 h / Ambient temperature

4: 92 percent / NaH / tetrahydrofuran / 0.33 h / 0 °C

5: 52 percent / diethyl ether / 1 h / 0 °C

6: 98 percent / pyridinium-p-toluenesulfonate / acetone; H₂O / 16 h / Heating

7: 45 percent / Na / CH₂Cl₂; ethanol / 0 °C

With chromium(III) oxide; n-butyllithium; ethylmagnesium bromide; sodium; pyridinium p-toluenesulfonate; sodium hydride; In tetrahydrofuran; pyridine; diethyl ether; ethanol; hexane; dichloromethane; water; acetone; toluene;
DOI:10.1002/hlca.19890720120