(S)-1-(biphenyl-4-yl)-3-(2-((S)-2-hydroxy-3-(1-(isoquinolin-4-yl)-1H-1,2,3-triazol-4-yl)propoxy)ethoxy)propan-2-ol

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Chemical Name:(S)-1-(biphenyl-4-yl)-3-(2-((S)-2-hydroxy-3-(1-(isoquinolin-4-yl)-1H-1,2,3-triazol-4-yl)propoxy)ethoxy)propan-2-ol
CAS No.:1608463-95-1
Molecular Formula:C₃₁H₃₂N₄O₄
Molecular Weight:524.619
Hs Code.:

Synonyms:(S)-1-(biphenyl-4-yl)-3-(2-((S)-2-hydroxy-3-(1-(isoquinolin-4-yl)-1H-1,2,3-triazol-4-yl)propoxy)ethoxy)propan-2-ol

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Chemical Property of (S)-1-(biphenyl-4-yl)-3-(2-((S)-2-hydroxy-3-(1-(isoquinolin-4-yl)-1H-1,2,3-triazol-4-yl)propoxy)ethoxy)propan-2-ol

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Technology Process of (S)-1-(biphenyl-4-yl)-3-(2-((S)-2-hydroxy-3-(1-(isoquinolin-4-yl)-1H-1,2,3-triazol-4-yl)propoxy)ethoxy)propan-2-ol

There total 10 articles about (S)-1-(biphenyl-4-yl)-3-(2-((S)-2-hydroxy-3-(1-(isoquinolin-4-yl)-1H-1,2,3-triazol-4-yl)propoxy)ethoxy)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₄₀N₄O₆

: 1608463-95-1
(S)-1-(biphenyl-4-yl)-3-(2-((S)-2-hydroxy-3-(1-(isoquinolin-4-yl)-1H-1,2,3-triazol-4-yl)propoxy)ethoxy)propan-2-ol

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; methanol; water; at 20 ℃; for 3h;
DOI:10.1016/j.ejmech.2014.03.062

Reference yield:

: 406218-43-7
(S)-2-((2-(benzyloxy)ethoxy)methyl)oxirane

: 1608463-95-1
(S)-1-(biphenyl-4-yl)-3-(2-((S)-2-hydroxy-3-(1-(isoquinolin-4-yl)-1H-1,2,3-triazol-4-yl)propoxy)ethoxy)propan-2-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: magnesium; copper(I) bromide / tetrahydrofuran / 4 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 h / 20 °C

4.1: benzyltriethylammonium chloride / 0.05 h

4.2: 22.58 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C / Inert atmosphere

5.2: 0.5 h / Inert atmosphere

5.3: 3 h / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / -10 °C

8.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / N,N-dimethyl-formamide; water / 85 °C

9.1: hydrogenchloride / water; tetrahydrofuran; methanol / 3 h / 20 °C

With hydrogenchloride; n-butyllithium; copper(ll) sulfate pentahydrate; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; magnesium; benzyltriethylammonium chloride; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; copper(I) bromide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.03.062

Reference yield:

: 1608463-85-9
(S)-1-(2-(benzyloxy)ethoxy)-3-(biphenyl-4-yl)propan-2-ol

: 1608463-95-1
(S)-1-(biphenyl-4-yl)-3-(2-((S)-2-hydroxy-3-(1-(isoquinolin-4-yl)-1H-1,2,3-triazol-4-yl)propoxy)ethoxy)propan-2-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 h / 20 °C

3.1: benzyltriethylammonium chloride / 0.05 h

3.2: 22.58 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C / Inert atmosphere

4.2: 0.5 h / Inert atmosphere

4.3: 3 h / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / -10 °C

7.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / N,N-dimethyl-formamide; water / 85 °C

8.1: hydrogenchloride / water; tetrahydrofuran; methanol / 3 h / 20 °C

With hydrogenchloride; n-butyllithium; copper(ll) sulfate pentahydrate; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; benzyltriethylammonium chloride; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.03.062