6-(4-methoxyphenyl)-3-(6-methylpyridine-2-yl)-1,2,4-triazine

Base Information

• Chemical Name: 6-(4-methoxyphenyl)-3-(6-methylpyridine-2-yl)-1,2,4-triazine
• CAS No.: 1263368-91-7
• Molecular Formula: C₁₆H₁₄N₄O
• Molecular Weight: 278.313
• Mol file: 1263368-91-7.mol

Synonyms:6-(4-methoxyphenyl)-3-(6-methylpyridine-2-yl)-1,2,4-triazine

Chemical Property of 6-(4-methoxyphenyl)-3-(6-methylpyridine-2-yl)-1,2,4-triazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-methoxyphenyl)-3-(6-methylpyridine-2-yl)-1,2,4-triazine

There total 5 articles about 6-(4-methoxyphenyl)-3-(6-methylpyridine-2-yl)-1,2,4-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

6-methyl-2-pyridinecarboxaldehyde (1122-72-1) + C9H11N3O2 (41939-98-4) → 6-(4-methoxyphenyl)-3-(6-methylpyridine-2-yl)-1,2,4-triazine (1263368-91-7)

Guidance literature:

6-methyl-2-pyridinecarboxaldehyde; C₉H₁₁N₃O₂; In ethanol; at 20 ℃; for 5h;

With acetic acid; at 90 ℃; for 0.5h;

DOI:10.1016/j.tet.2010.11.058

Reference yield:

C16H16N4O2 → 6-(4-methoxyphenyl)-3-(6-methylpyridine-2-yl)-1,2,4-triazine (1263368-91-7)

Guidance literature:

With acetic acid; for 1h; Cooling;

DOI:10.1134/S1070428017070016

Reference yield:

6-methyl-2-pyridinecarboxaldehyde (1122-72-1) → 6-(4-methoxyphenyl)-3-(6-methylpyridine-2-yl)-1,2,4-triazine (1263368-91-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 10 h / 20 °C

2: acetic acid / 1 h / Cooling

With acetic acid; In ethanol;

DOI:10.1134/S1070428017070016

upstream raw materials:

6-methyl-2-pyridinecarboxaldehyde

C₉H₁₁N₃O₂

2-(Hydroxymethyl)-6-methylpyridine

Downstream raw materials:

C₄₄H₆₄N₆O₇

Br^(1-)*C₂₈H₃₃N₆O⁽¹⁺⁾

C₂₆H₃₄N₆O