Technology Process of 2-((3S,8S)-3-(3,4-dichlorophenyl)-2,3,7,8-tetrahydrobenzofuro[5,6-b][1,4]dioxin-8-yl)acetic acid
There total 9 articles about 2-((3S,8S)-3-(3,4-dichlorophenyl)-2,3,7,8-tetrahydrobenzofuro[5,6-b][1,4]dioxin-8-yl)acetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
acetic acid;
In
isopropyl alcohol;
Resolution of racemate;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene / 3 h / 50 °C / Inert atmosphere
2: tetrabutyl ammonium fluoride / dichloromethane; tetrahydrofuran / 2 h / Inert atmosphere
3: palladium diacetate; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; caesium carbonate / toluene / 12 h / 50 °C / Inert atmosphere
4: sodium hydroxide / methanol / 1 h / 60 °C / Inert atmosphere
5: acetic acid / isopropyl alcohol / Resolution of racemate; Inert atmosphere
With
racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; tributylphosphine; tetrabutyl ammonium fluoride; palladium diacetate; caesium carbonate; acetic acid; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine;
In
tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: palladium diacetate; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; caesium carbonate / toluene / 12 h / 50 °C / Inert atmosphere
2: sodium hydroxide / methanol / 1 h / 60 °C / Inert atmosphere
3: acetic acid / isopropyl alcohol / Resolution of racemate; Inert atmosphere
With
racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; palladium diacetate; caesium carbonate; acetic acid; sodium hydroxide;
In
methanol; isopropyl alcohol; toluene;