(R)-4-(5-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide

Base Information

Chemical Name:(R)-4-(5-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide
CAS No.:1276687-90-1
Molecular Formula:C₂₉H₂₉F₃N₄O₃
Molecular Weight:538.569
Hs Code.:

Synonyms:(R)-4-(5-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide

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Chemical Property of (R)-4-(5-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide

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Technology Process of (R)-4-(5-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide

There total 10 articles about (R)-4-(5-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1276687-86-5
methyl (R)-4-(5-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate

: 1276687-90-1
(R)-4-(5-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide

Guidance literature:: With ammonia; In methanol; at 75 ℃; for 144h;
DOI:10.1021/jm1011726

Reference yield:

: 1276687-88-7
C₂₉H₂₈F₃N₃O₄

: 1276687-90-1
(R)-4-(5-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; acetic acid / methanol; dichloromethane; water / 2 h / 20 °C

2: ammonia / methanol / 144 h / 75 °C

With ammonia; sodium tris(acetoxy)borohydride; acetic acid; In methanol; dichloromethane; water;
DOI:10.1021/jm1011726

Reference yield:

: 1276687-74-1
methyl (R)-4-nitro-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate

: 1276687-90-1
(R)-4-(5-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: palladium 10% on activated carbon; hydrogen / methanol; water / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 60 °C

3: hydrogen; pyridinium p-toluenesulfonate / ethyl acetate / 20 °C

4: trifluoroacetic acid / dichloromethane / 0 - 20 °C

5: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 0 - 20 °C

6: trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C

7: sodium tris(acetoxy)borohydride; acetic acid / methanol; dichloromethane; water / 2 h / 20 °C

8: ammonia / methanol / 144 h / 75 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butyl-diazodicarboxylate; palladium 10% on activated carbon; ammonia; hydrogen; pyridinium p-toluenesulfonate; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; 2: Buchwald-Hartwig reaction / 5: Mitsunobu reaction;
DOI:10.1021/jm1011726