Technology Process of (3S)-2',4'-dimethoxy-7-hydroxyisoflavanone
There total 7 articles about (3S)-2',4'-dimethoxy-7-hydroxyisoflavanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium on activated carbon; hydrogen;
In
ethyl acetate;
at 20 ℃;
for 18h;
under 760.051 Torr;
enantioselective reaction;
Inert atmosphere;
DOI:10.1002/chem.201405246
- Guidance literature:
-
With
Chiralpak IC column (20*250 mm, 5 μm, Daicel Industries);
In
methanol;
at 35 ℃;
under 75007.5 Torr;
Resolution of racemate;
DOI:10.1016/j.tetasy.2016.09.002
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / butanone / 18 h / Reflux
2.1: n-butyllithium; lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h
2.2: 1 h
3.1: pyridine / chloroform / 18 h / 40 °C
4.1: palladium diacetate; formic acid; (S)-4-tert-butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazol / tetrahydrofuran / 10 h / 40 °C / Molecular sieve; Schlenk technique; Inert atmosphere
5.1: palladium on activated carbon; hydrogen / ethyl acetate / 18 h / 20 °C / 760.05 Torr / Inert atmosphere
With
pyridine; n-butyllithium; formic acid; palladium on activated carbon; hydrogen; palladium diacetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; (S)-4-tert-butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazol; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane; chloroform; ethyl acetate; butanone;
DOI:10.1002/chem.201405246
