N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloro-N-(1-(3-(trifluoromethoxy)phenyl)-1H-indol-5-yl)pyrimidine-5-carboxamide

Base Information

Chemical Name:N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloro-N-(1-(3-(trifluoromethoxy)phenyl)-1H-indol-5-yl)pyrimidine-5-carboxamide
CAS No.:1610800-68-4
Molecular Formula:C₂₈H₂₉Cl₂F₃N₄O₃Si
Molecular Weight:625.55
Hs Code.:

Synonyms:N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloro-N-(1-(3-(trifluoromethoxy)phenyl)-1H-indol-5-yl)pyrimidine-5-carboxamide

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Chemical Property of N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloro-N-(1-(3-(trifluoromethoxy)phenyl)-1H-indol-5-yl)pyrimidine-5-carboxamide

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Technology Process of N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloro-N-(1-(3-(trifluoromethoxy)phenyl)-1H-indol-5-yl)pyrimidine-5-carboxamide

There total 5 articles about N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloro-N-(1-(3-(trifluoromethoxy)phenyl)-1H-indol-5-yl)pyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1610800-66-2
N-(2-(tert-butyldimethylsilyloxy)ethyl)-1-(3-(trifluoromethoxy)phenyl)-1H-indol-5-amine

: 87600-97-3
4,6-dichloropyrimidine-5-carboxylic acid chloride

: 1610800-68-4
N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloro-N-(1-(3-(trifluoromethoxy)phenyl)-1H-indol-5-yl)pyrimidine-5-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; for 2h; Cooling with ice;

Reference yield:

: 1610800-64-0
5-bromo-1-(3-(trifluoromethoxy)phenyl)-1H-indole

: 1610800-68-4
N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloro-N-(1-(3-(trifluoromethoxy)phenyl)-1H-indol-5-yl)pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; caesium carbonate; 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl / toluene / 4 h / 110 °C / Reflux; Inert atmosphere

2: triethylamine / dichloromethane / 2 h / Cooling with ice

With 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl; palladium diacetate; caesium carbonate; triethylamine; In dichloromethane; toluene;

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 1610800-68-4
N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloro-N-(1-(3-(trifluoromethoxy)phenyl)-1H-indol-5-yl)pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: copper(I) bromide; potassium carbonate; sodium hydroxide; copper diacetate / N,N-dimethyl-formamide / 16.17 h / 100 - 110 °C

2: palladium diacetate; caesium carbonate; 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl / toluene / 4 h / 110 °C / Reflux; Inert atmosphere

3: triethylamine / dichloromethane / 2 h / Cooling with ice

With 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl; copper diacetate; palladium diacetate; potassium carbonate; caesium carbonate; triethylamine; copper(I) bromide; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide; toluene;