1-cyclopropyl-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Base Information

Chemical Name:1-cyclopropyl-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
CAS No.:1357592-87-0
Molecular Formula:C₁₇H₁₆N₄O₂
Molecular Weight:308.34
Hs Code.:

Synonyms:1-cyclopropyl-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

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Chemical Property of 1-cyclopropyl-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

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Technology Process of 1-cyclopropyl-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

There total 9 articles about 1-cyclopropyl-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.3%

: 4333-56-6,130561-87-4
cyclopropyl bromide

: 1357192-32-5
5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4-ol

: 1357592-87-0
1-cyclopropyl-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 30h; Autoclave;
DOI:10.1016/j.bmc.2016.05.049

Reference yield:

: 1357192-31-4
1-benzyl-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

: 1357592-87-0
1-cyclopropyl-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; tetrahydrofuran / 48 h / 20 °C

2: sodium iodide; caesium carbonate / N,N-dimethyl-formamide / 30 h / 20 - 150 °C / Autoclave

With 10 wt% Pd(OH)2 on carbon; hydrogen; caesium carbonate; sodium iodide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1357192-30-3
1-benzyl-3-chloro-5-methoxypyridazin-4(1H)-one

: 1357592-87-0
1-cyclopropyl-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium carbonate / water; toluene / 24 °C / Reflux; Inert atmosphere

2: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; tetrahydrofuran / 48 h / 20 °C

3: sodium iodide; caesium carbonate / N,N-dimethyl-formamide / 30 h / 20 - 150 °C / Autoclave

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); 10 wt% Pd(OH)2 on carbon; hydrogen; potassium carbonate; caesium carbonate; sodium iodide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;