(3'R,4'S)-6-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester

Base Information

Chemical Name:(3'R,4'S)-6-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester
CAS No.:1026786-82-2
Molecular Formula:C₂₅H₃₀Cl₂N₂O₆
Molecular Weight:525.429
Hs Code.:

Synonyms:(3'R,4'S)-6-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester

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Chemical Property of (3'R,4'S)-6-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester

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Technology Process of (3'R,4'S)-6-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester

There total 29 articles about (3'R,4'S)-6-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1265907-55-8
(3'S,4'S)-6-[2-(2,6-dichloro-4-methyl-phenoxy)ethoxy]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester 3'-ethyl ester

: 1026786-82-2
(3'R,4'S)-6-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester

Guidance literature:: (3'S,4'S)-6-[2-(2,6-dichloro-4-methyl-phenoxy)ethoxy]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester 3'-ethyl ester; With sodium ethanolate; In ethanol; at 70 ℃; for 1h; Inert atmosphere; Large scale reaction;

With sodium hydroxide; In ethanol; water; at 70 ℃; for 1h; optical yield given as %de; Inert atmosphere; Large scale reaction;
DOI:10.1021/jo102070e

Reference yield: 30.0%

: (rac.)-(3R*,4S*)-6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester

: 1026786-82-2
(3'R,4'S)-6-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester

: (3S,4R)-4-(6-(2-(2,6-dichloro-4-methyl-phenoxy)ethoxy)-pyridin-3-yl)piperidine-1,3-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: With trifluoroacetic acid; In ethanol; hexane; Purification / work up; Resolution of racemate;

Reference yield:

: C₂₇H₃₄Cl₂N₂O₆

: 1026786-82-2
(3'R,4'S)-6-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester

Guidance literature:: C₂₇H₃₄Cl₂N₂O₆; With sodium hydroxide; In ethanol; water; at 70 ℃;

With hydrogenchloride; In ethanol; water; isopropyl alcohol; at 10 - 20 ℃;