N⁴-[(3R,4R)-1-benzyl-4-methyl-3-piperidinyl]-N⁴-methyl-2,3,4-pyridinetriamine

Base Information

• Chemical Name: N⁴-[(3R,4R)-1-benzyl-4-methyl-3-piperidinyl]-N⁴-methyl-2,3,4-pyridinetriamine
• CAS No.: 920965-91-9
• Molecular Formula: C₁₉H₂₇N₅
• Molecular Weight: 325.457
• Mol file: 920965-91-9.mol

Synonyms:N⁴-[(3R,4R)-1-benzyl-4-methyl-3-piperidinyl]-N⁴-methyl-2,3,4-pyridinetriamine

Chemical Property of N⁴-[(3R,4R)-1-benzyl-4-methyl-3-piperidinyl]-N⁴-methyl-2,3,4-pyridinetriamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-[(3R,4R)-1-benzyl-4-methyl-3-piperidinyl]-N⁴-methyl-2,3,4-pyridinetriamine

There total 3 articles about N⁴-[(3R,4R)-1-benzyl-4-methyl-3-piperidinyl]-N⁴-methyl-2,3,4-pyridinetriamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-N-[(3R,4R)-1-benzyl-4-methylpiperidin-3-yl]-4-N-methyl-3-nitropyridine-2,4-diamine (920965-88-4) → N4-[(3R,4R)-1-benzyl-4-methyl-3-piperidinyl]-N4-methyl-2,3,4-pyridinetriamine (920965-91-9)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; for 4h; Heating / reflux;

Reference yield:

4-chloro-3-nitro-2-pyridinamine (6980-08-1) → N4-[(3R,4R)-1-benzyl-4-methyl-3-piperidinyl]-N4-methyl-2,3,4-pyridinetriamine (920965-91-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 60 h / 80 °C / Inert atmosphere; Sealed tube

2: hydrogenchloride; zinc; ammonium formate / water; ethanol / 4 h / 20 °C

With hydrogenchloride; ammonium formate; N-ethyl-N,N-diisopropylamine; zinc; In 1,4-dioxane; ethanol; water;

DOI:10.1002/cmdc.201402252

Reference yield:

N-(3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine (477600-70-7,1354621-59-2,1431697-80-1,477600-69-4) → N4-[(3R,4R)-1-benzyl-4-methyl-3-piperidinyl]-N4-methyl-2,3,4-pyridinetriamine (920965-91-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 60 h / 80 °C / Inert atmosphere; Sealed tube

2: hydrogenchloride; zinc; ammonium formate / water; ethanol / 4 h / 20 °C

With hydrogenchloride; ammonium formate; N-ethyl-N,N-diisopropylamine; zinc; In 1,4-dioxane; ethanol; water;

DOI:10.1002/cmdc.201402252

upstream raw materials:

4-N-[(3R,4R)-1-benzyl-4-methylpiperidin-3-yl]-4-N-methyl-3-nitropyridine-2,4-diamine

4-chloro-3-nitro-2-pyridinamine

N-(3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine