5,6-dimethoxy-2,2-bis(3,4-dimethoxybenzyl)-2,3-dihydro-1H-indene-1,3-dione

Base Information

• Chemical Name: 5,6-dimethoxy-2,2-bis(3,4-dimethoxybenzyl)-2,3-dihydro-1H-indene-1,3-dione
• CAS No.: 888701-47-1
• Molecular Formula: C₂₉H₃₀O₈
• Molecular Weight: 506.552
• Mol file: 888701-47-1.mol

Synonyms:5,6-dimethoxy-2,2-bis(3,4-dimethoxybenzyl)-2,3-dihydro-1H-indene-1,3-dione

Chemical Property of 5,6-dimethoxy-2,2-bis(3,4-dimethoxybenzyl)-2,3-dihydro-1H-indene-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,6-dimethoxy-2,2-bis(3,4-dimethoxybenzyl)-2,3-dihydro-1H-indene-1,3-dione

There total 5 articles about 5,6-dimethoxy-2,2-bis(3,4-dimethoxybenzyl)-2,3-dihydro-1H-indene-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-(3,4-dimethoxybenzyl)-2,3-dihydro-5,6-dimethoxy-1H-indene-1,3-dione (888701-46-0) + 4-chloromethyl-1,2-dimethoxy-benzene (7306-46-9) → 5,6-dimethoxy-2,2-bis(3,4-dimethoxybenzyl)-2,3-dihydro-1H-indene-1,3-dione (888701-47-1) + 5,6-dimethoxy-2-(3,4-dimethoxybenzyl)-2-[3,4-dimethoxy-6-(3,4-dimethoxybenzyl)benzyl]-2,3-dihydro-1H-indene-1,3-dione

Guidance literature:

With potassium fluoride; Celite; In acetonitrile; at 75 ℃; for 3h;

DOI:10.1002/ejoc.200501005

Reference yield: 38.0%

4-bromomethyl-1,2-dimethoxybenzene (21852-32-4) + 2,3-dihydro-5,6-dimethoxy-1H-indene-1,3-dione (36517-91-6) → 5,6-dimethoxy-2,2-bis(3,4-dimethoxybenzyl)-2,3-dihydro-1H-indene-1,3-dione (888701-47-1) + 5,6-dimethoxy-2-(3,4-dimethoxybenzyl)-2-[3,4-dimethoxy-6-(3,4-dimethoxybenzyl)benzyl]-2,3-dihydro-1H-indene-1,3-dione

Guidance literature:

With potassium fluoride; Celite; In acetonitrile; at 75 ℃; for 4h;

DOI:10.1002/ejoc.200501005

Reference yield:

2,3-dihydro-5,6-dimethoxy-1H-indene-1,3-dione (36517-91-6) → 5,6-dimethoxy-2,2-bis(3,4-dimethoxybenzyl)-2,3-dihydro-1H-indene-1,3-dione (888701-47-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / acetic acid / 2 h / Heating

2: 84 percent / sodium borohydride / pyridine / 0.33 h / 60 °C

3: 79 percent / potassium fluoride/celite 545 / acetonitrile / 3 h / 75 °C

With potassium fluoride; sodium tetrahydroborate; Celite; In pyridine; acetic acid; acetonitrile;

DOI:10.1002/ejoc.200501005

upstream raw materials:

4-bromomethyl-1,2-dimethoxybenzene

2,3-dihydro-5,6-dimethoxy-1H-indene-1,3-dione

2-(3,4-dimethoxybenzyl)-2,3-dihydro-5,6-dimethoxy-1H-indene-1,3-dione

4-chloromethyl-1,2-dimethoxy-benzene

Downstream raw materials:

C₂₉H₃₄O₈