(2S,4R)-Boc-4-cyclohexyl-pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:(2S,4R)-Boc-4-cyclohexyl-pyrrolidine-2-carboxylic acid
CAS No.:934470-83-4
Molecular Formula:C₁₆H₂₇NO₄
Molecular Weight:297.395
Hs Code.:
Mol file:934470-83-4.mol

Synonyms:(2S,4S)-4-cyclohexyl-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

Suppliers and Price of (2S,4R)-Boc-4-cyclohexyl-pyrrolidine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(2S,4R)-1-(tert-Butoxycarbonyl)-4-cyclohexylpyrrolidine-2-carboxylicacid 95+%
1g
$ 554.00

AK Scientific
(2S,4R)-Boc-4-cyclohexyl-pyrrolidine-2-carboxylicacid
1g
$ 1224.00

AK Scientific
(2S,4R)-Boc-4-cyclohexyl-pyrrolidine-2-carboxylicacid
250mg
$ 637.00

AK Scientific
(2S,4R)-Boc-4-cyclohexyl-pyrrolidine-2-carboxylicacid
100mg
$ 353.00

AK Scientific
(2S,4R)-Boc-4-cyclohexyl-pyrrolidine-2-carboxylicacid
25mg
$ 144.00

Total 2 raw suppliers

Chemical Property of (2S,4R)-Boc-4-cyclohexyl-pyrrolidine-2-carboxylic acid

Chemical Property:

Boiling Point:426.6±38.0 °C(Predicted)
PKA:4.01±0.40(Predicted)
Density:1.146±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

(2S,4R)-1-(tert-Butoxycarbonyl)-4-cyclohexylpyrrolidine-2-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4R)-Boc-4-cyclohexyl-pyrrolidine-2-carboxylic acid

There total 5 articles about (2S,4R)-Boc-4-cyclohexyl-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 934470-78-7
1-tert-butyl 2-ethyl (2S,4S)-4-cyclohexyl-1,2-pyrrolidinedicarboxylate

: 934470-83-4,394734-77-1
(2S,4S)-4-cyclohexyl-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 20 ℃; for 6h;
DOI:10.1016/j.bmc.2007.01.033

Reference yield:

: 934470-73-2
1-tert-butyl 2-ethyl (2S,4R)-4-cyclohexyl-5-oxo-1,2-pyrrolidinedicarboxylate

: 934470-83-4,394734-77-1
(2S,4S)-4-cyclohexyl-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium triethylborohydride / tetrahydrofuran / 0.67 h / -78 °C

1.2: H₂O₂ / tetrahydrofuran / 0.33 h / 0 °C

1.3: 98 percent / triethylsilane; BF₃*OEt₂ / CH₂Cl₂ / 3 h / -78 °C

2.1: 89 percent / NaOH / methanol; H₂O / 6 h / 20 °C

With sodium hydroxide; lithium triethylborohydride; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmc.2007.01.033

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 934470-83-4,394734-77-1
(2S,4S)-4-cyclohexyl-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

1.2: 80 percent / BF₃*OEt₂ / tetrahydrofuran / 2.5 h / -78 °C

2.1: methanesulfonyl chloride; triethylamine / CH₂Cl₂ / 48 h / 20 °C

2.2: 527 mg / hydrogen / platinum(IV) oxide / ethyl acetate / 18 h / 20 °C / atmospheric pressure

3.1: lithium triethylborohydride / tetrahydrofuran / 0.67 h / -78 °C

3.2: H₂O₂ / tetrahydrofuran / 0.33 h / 0 °C

3.3: 98 percent / triethylsilane; BF₃*OEt₂ / CH₂Cl₂ / 3 h / -78 °C

4.1: 89 percent / NaOH / methanol; H₂O / 6 h / 20 °C

With sodium hydroxide; lithium triethylborohydride; methanesulfonyl chloride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2007.01.033