5-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-3-phenylisoxazole

Base Information

Chemical Name:5-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-3-phenylisoxazole
CAS No.:227617-32-5
Molecular Formula:C₁₄H₁₅NO₃
Molecular Weight:245.278
Hs Code.:
DSSTox Substance ID:DTXSID201198074

Synonyms:DTXSID201198074;5-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-3-phenylisoxazole;227617-32-5

Suppliers and Price of 5-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-3-phenylisoxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-3-phenylisoxazole

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:245.10519334
Heavy Atom Count:18
Complexity:289

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(OCC(O1)C2=CC(=NO2)C3=CC=CC=C3)C
Isomeric SMILES:CC1(OC[C@@H](O1)C2=CC(=NO2)C3=CC=CC=C3)C

Technology Process of 5-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-3-phenylisoxazole

There total 6 articles about 5-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-3-phenylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: (Z)-3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-1-phenyl-propenone oxime

: 227617-32-5
3-phenyl-5-(1,2-O-isopropylidene-D-glycero-dihydroxyethyl)isoxazole

Guidance literature:: With iodine; sodium hydrogencarbonate; potassium iodide; In tetrahydrofuran; methanol; water; Heating;

Reference yield: 55.0%

: (E)-3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-1-phenyl-propenone oxime

: 227617-32-5
3-phenyl-5-(1,2-O-isopropylidene-D-glycero-dihydroxyethyl)isoxazole

Guidance literature:: With iodine; sodium hydrogencarbonate; potassium iodide; In tetrahydrofuran; methanol; water; Heating;

Reference yield:

: 20913-05-7,859-65-4
(Benzoylmethylene)triphenylphosphorane

: 227617-32-5
3-phenyl-5-(1,2-O-isopropylidene-D-glycero-dihydroxyethyl)isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: 24 percent / CH₂Cl₂ / 6 h / Ambient temperature

2: NH₂OH*HCl / methanol; pyridine / Ambient temperature

3: 55 percent / KI, I₂, NaHCO₃ / methanol; tetrahydrofuran; H₂O / Heating

With hydroxylamine hydrochloride; iodine; sodium hydrogencarbonate; potassium iodide; In tetrahydrofuran; pyridine; methanol; dichloromethane; water;