1-(4-[4-[(5RS)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazole-2-yl]-1-piperidinyl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

Base Information

• Chemical Name: 1-(4-[4-[(5RS)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazole-2-yl]-1-piperidinyl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone
• CAS No.: 1003318-67-9
• Molecular Formula: C₂₄H₂₂F₅N₅O₂S
• Molecular Weight: 539.529
• Mol file: 1003318-67-9.mol

Synonyms:1-(4-[4-[(5RS)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazole-2-yl]-1-piperidinyl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

Chemical Property of 1-(4-[4-[(5RS)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazole-2-yl]-1-piperidinyl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

Chemical Property:

• Boiling Point: 613.9±65.0 °C(Predicted)
• Density: 1.54±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Zorvec ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Oxathiapiprolin is now registered in numerous countries around the world, including Australia, Canada, China, Japan, and the United States, with the reviews confirming a highly favorable toxicological and environmental profile.
• Physical properties: Melting point 146–148 °C (Form B) Water solubility 0.175 mg l?1 log Kow 3.67 Kfoc 8368 g kg?1 Vapor pressure (20 °C) 1.14 × 10?6 Pa Hydrolysis Stable Aqueous photolysis DT50 ~ 15 d Degradation in soil DT50 ~ 90 d

Technology Process of 1-(4-[4-[(5RS)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazole-2-yl]-1-piperidinyl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

There total 3 articles about 1-(4-[4-[(5RS)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazole-2-yl]-1-piperidinyl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidine-4-carbothioic acid amide (1003319-95-6) + 2-chloro-1-[5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3-yl]ethanone (1253189-14-8) → 1-(4-[4-[(5RS)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazole-2-yl]-1-piperidinyl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (1003318-67-9)

Guidance literature:

1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidine-4-carbothioic acid amide; 2-chloro-1-[5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3-yl]ethanone; With sodium bromide; In acetone; for 3h; Reflux;

With sodium hydrogencarbonate; In acetone; for 0.5h;

Reference yield:

1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidine-4-carbothioic acid amide (1003319-95-6) + 2-bromo-1-(4,5-dihydro-5-(2,6-difluorophenyl)-3-isoxazolyl)ethanone (1173693-37-2) → 1-(4-[4-[(5RS)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazole-2-yl]-1-piperidinyl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (1003318-67-9)

Guidance literature:

In methanol; at 20 - 55 ℃; for 1h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

→ 1-(4-[4-[(5RS)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazole-2-yl]-1-piperidinyl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (1003318-67-9)

Guidance literature:

upstream raw materials:

1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidine-4-carbothioic acid amide

2-bromo-1-(4,5-dihydro-5-(2,6-difluorophenyl)-3-isoxazolyl)ethanone

2-chloro-1-[5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3-yl]ethanone

Refernces

• 1、 -. "SOLID FORMS OF AN AZOCYCLIC AMIDE". Page/Page column 22. . Retrieved 2010/11/05.