5-cyclopropyl-2-(4-fluorophenyl)-6-(N-((2-hydroxy-1,2-oxaborolan-4-yl)methyl)ethylsulfonamido)-N-methylbenzofuran-3-carboxamide

Base Information

Chemical Name:5-cyclopropyl-2-(4-fluorophenyl)-6-(N-((2-hydroxy-1,2-oxaborolan-4-yl)methyl)ethylsulfonamido)-N-methylbenzofuran-3-carboxamide
CAS No.:1378427-50-9
Molecular Formula:C₂₅H₂₈BFN₂O₆S
Molecular Weight:514.383
Hs Code.:

Synonyms:5-cyclopropyl-2-(4-fluorophenyl)-6-(N-((2-hydroxy-1,2-oxaborolan-4-yl)methyl)ethylsulfonamido)-N-methylbenzofuran-3-carboxamide

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Chemical Property of 5-cyclopropyl-2-(4-fluorophenyl)-6-(N-((2-hydroxy-1,2-oxaborolan-4-yl)methyl)ethylsulfonamido)-N-methylbenzofuran-3-carboxamide

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Technology Process of 5-cyclopropyl-2-(4-fluorophenyl)-6-(N-((2-hydroxy-1,2-oxaborolan-4-yl)methyl)ethylsulfonamido)-N-methylbenzofuran-3-carboxamide

There total 5 articles about 5-cyclopropyl-2-(4-fluorophenyl)-6-(N-((2-hydroxy-1,2-oxaborolan-4-yl)methyl)ethylsulfonamido)-N-methylbenzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1378429-67-4
6-(N-(3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propyl)ethylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran carboxamide

: 1378427-50-9
5-cyclopropyl-2-(4-fluorophenyl)-6-(N-((2-hydroxy-1,2-oxaborolan-4-yl)methyl)ethylsulfonamido)-N-methylbenzofuran-3-carboxamide

Guidance literature:: 6-(N-(3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propyl)ethylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran carboxamide; With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 16h; under 2585.81 Torr;

With hydrogenchloride; In tetrahydrofuran; water; for 2h;

Reference yield:

: ethyl 5-cyclopropyl-6-(N-(ethylsulfonyl)ethylsulfonamido)-2-(4-fluorophenyl)benzofuran-3-carboxylate

: 1378427-50-9
5-cyclopropyl-2-(4-fluorophenyl)-6-(N-((2-hydroxy-1,2-oxaborolan-4-yl)methyl)ethylsulfonamido)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide; water / ethanol / 1 h / Reflux; Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 21 °C / Inert atmosphere

2.2: 2 h

3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

4.1: carbonylbis(triphenylphosphine)rhodium⁽¹⁾chloride / tetrahydrofuran / 3 h / Inert atmosphere

5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 16 h / 20 °C / 2585.81 Torr

5.2: PS-benzene boronic acid / 2 h

With water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium iodide; potassium hydroxide; palladium 10% on activated carbon; carbonylbis(triphenylphosphine)rhodium⁽¹⁾chloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1352809-25-6
5-cyclopropyl-6-(ethylsulfonamido)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

: 1378427-50-9
5-cyclopropyl-2-(4-fluorophenyl)-6-(N-((2-hydroxy-1,2-oxaborolan-4-yl)methyl)ethylsulfonamido)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.1: carbonylbis(triphenylphosphine)rhodium⁽¹⁾chloride / tetrahydrofuran / 3 h / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 16 h / 20 °C / 2585.81 Torr

3.2: PS-benzene boronic acid / 2 h

With hydrogen; potassium carbonate; potassium iodide; palladium 10% on activated carbon; carbonylbis(triphenylphosphine)rhodium⁽¹⁾chloride; In tetrahydrofuran; N,N-dimethyl-formamide;