tert-butyl 3-(4-chlorophenyl)-3-((2-methoxyphenyl)amino)-2,2-dimethylpropanoate

Base Information

Chemical Name:tert-butyl 3-(4-chlorophenyl)-3-((2-methoxyphenyl)amino)-2,2-dimethylpropanoate
CAS No.:1391597-37-7
Molecular Formula:C₂₂H₂₈ClNO₃
Molecular Weight:389.922
Hs Code.:

Synonyms:tert-butyl 3-(4-chlorophenyl)-3-((2-methoxyphenyl)amino)-2,2-dimethylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 3-(4-chlorophenyl)-3-((2-methoxyphenyl)amino)-2,2-dimethylpropanoate

Chemical Property:

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Technology Process of tert-butyl 3-(4-chlorophenyl)-3-((2-methoxyphenyl)amino)-2,2-dimethylpropanoate

There total 2 articles about tert-butyl 3-(4-chlorophenyl)-3-((2-methoxyphenyl)amino)-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 16889-72-8
tert-butyl 2-methylpropanoate

: 63462-36-2
N-(4-chlorobenzylidene)-2-methoxybenzenamine

: 1391597-37-7
tert-butyl 3-(4-chlorophenyl)-3-((2-methoxyphenyl)amino)-2,2-dimethylpropanoate

Guidance literature:: With potassium hydride; In tert-butyl methyl ether; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1039/c2ob25522g

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 90-04-0
2-methoxy-phenylamine

: 1391597-37-7
tert-butyl 3-(4-chlorophenyl)-3-((2-methoxyphenyl)amino)-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: Molecular sieve

2: potassium hydride / tert-butyl methyl ether / 12 h / 20 °C / Inert atmosphere

With potassium hydride; In tert-butyl methyl ether; 2: Mannich reaction;
DOI:10.1039/c2ob25522g