1-((tert-Butoxycarbonyl)aMino)-2,2-difluorocyclopropanecarboxylic acid

Base Information

• Chemical Name: 1-((tert-Butoxycarbonyl)aMino)-2,2-difluorocyclopropanecarboxylic acid
• CAS No.: 796882-45-6
• Molecular Formula: C₉H₁₃F₂NO₄
• Molecular Weight: 237.203
• Hs Code.: 2924299090
• Mol file: 796882-45-6.mol

Synonyms:Cyclopropanecarboxylicacid,1-[[(1,1-dimethylethoxy)carbonyl]amino]-2,2-difluoro;1-((tert-Butoxycarbonyl)amino)-2,2-difluorocyclopropanecarboxylic acid;

Chemical Property of 1-((tert-Butoxycarbonyl)aMino)-2,2-difluorocyclopropanecarboxylic acid

Chemical Property:

• Vapor Pressure: 7.63E-06mmHg at 25°C
• Boiling Point: 350.3°C at 760 mmHg
• Flash Point: 165.7°C
• PSA: 75.63000
• Density: 1.34g/cm³
• LogP: 1.76440
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-(tert-Butoxycarbonylamino)-2,2-difluorocyclopropanecarboxylic acid 97+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-((tert-Butoxycarbonyl)aMino)-2,2-difluorocyclopropanecarboxylic acid

There total 6 articles about 1-((tert-Butoxycarbonyl)aMino)-2,2-difluorocyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

1-[(tert-butoxyl)carbonylamino]-2,2-difluoro-1-(4-methoxyphenyl)cyclopropane → 1-[(tert-butoxyl)carbonylamino]-2,2-difluorocyclopropane-1-carboxylic acid (796882-45-6)

Guidance literature:

With sodium periodate; rhodium(III) chloride hydrate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01570

Reference yield:

C18H21F2NO6 → 1-[(tert-butoxyl)carbonylamino]-2,2-difluorocyclopropane-1-carboxylic acid (796882-45-6)

Guidance literature:

With methanol; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

tert-butyl (R)-(+)-N-[2,2-difluoro-1-(hydroxymethyl)cyclopropyl]carbamate → 1-tert-butoxycarbonylamino-2,2-difluoro-cyclopropanecarboxylic acid (228580-13-0,796882-45-6)

Guidance literature:

at 20 ℃;

DOI:10.1246/cl.1999.405

upstream raw materials:

(R)-(+)-{2,2-difluoro-1-[(tert-butoxy)carbonylamino]cyclopropyl}methyl acetate

(S)-(-)-{2,2-difluoro-1-[(tert-butoxy)carbonylamino]cyclopropyl}methyl acetate

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