4-amino-2-benzyloxy-benzoic acid-(3-piperidino-propyl ester)

Base Information

• Chemical Name: 4-amino-2-benzyloxy-benzoic acid-(3-piperidino-propyl ester)
• CAS No.: 100347-83-9
• Molecular Formula: C₂₂H₂₈N₂O₃
• Molecular Weight: 368.476
• Mol file: 100347-83-9.mol

Synonyms:4-amino-2-benzyloxy-benzoic acid-(3-piperidino-propyl ester)

Chemical Property of 4-amino-2-benzyloxy-benzoic acid-(3-piperidino-propyl ester)

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-amino-2-benzyloxy-benzoic acid-(3-piperidino-propyl ester)

There total 9 articles about 4-amino-2-benzyloxy-benzoic acid-(3-piperidino-propyl ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-benzyloxy-4-nitro-benzoic acid-(3-piperidino-propyl ester) → 4-amino-2-benzyloxy-benzoic acid-(3-piperidino-propyl ester) (100347-83-9)

Guidance literature:

With hydrogenchloride; iron;

DOI:10.1021/ja01152a032

Reference yield:

N-(3-chloropropyl)-piperidine (1458-63-5) → 4-amino-2-benzyloxy-benzoic acid-(3-piperidino-propyl ester) (100347-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: isopropyl alcohol

2: aq.-ethanolic hydrochloric acid; iron-powder

With hydrogenchloride; iron; isopropyl alcohol;

DOI:10.1021/ja01152a032

Reference yield:

2-hydroxy-4-nitrobenzoic acid (619-19-2) → 4-amino-2-benzyloxy-benzoic acid-(3-piperidino-propyl ester) (100347-83-9)

Guidance literature:

Multi-step reaction with 4 steps

1: Na₂CO₃; NaI; ethanol

2: aq.-ethanolic Na₂CO₃

3: isopropyl alcohol

4: aq.-ethanolic hydrochloric acid; iron-powder

With hydrogenchloride; ethanol; iron; sodium carbonate; isopropyl alcohol; sodium iodide;

DOI:10.1021/ja01152a032

upstream raw materials:

N-(3-chloropropyl)-piperidine

2-hydroxy-4-nitrobenzoic acid

2-methoxy-4-nitrobenzonitrile

2-hydroxy-4-nitro-benzoic acid ethyl ester

Downstream raw materials:

4-amino-2-hydroxy-benzoic acid-(3-piperidino-propyl ester)