1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-4-ethyl-N-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

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Chemical Name:1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-4-ethyl-N-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide
CAS No.:1574113-03-3
Molecular Formula:C₂₇H₃₀ClF₃N₂O
Molecular Weight:490.996
Hs Code.:

Synonyms:1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-4-ethyl-N-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

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Chemical Property of 1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-4-ethyl-N-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

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Technology Process of 1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-4-ethyl-N-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

There total 10 articles about 1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-4-ethyl-N-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 4433-63-0
Ethyl boronic acid

: 1574118-76-5
1-benzyl-4-bromo-3-(4-chlorophenyl)-N-(2,2-dimethylpropyl)-N-methyl-5-(trifluoromethyl)pyrrole-2-carboxamide

: 1574113-03-3
1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-4-ethyl-N-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

Guidance literature:: With palladium diacetate; XPhos; In toluene; at 120 ℃;

Reference yield:

: 1574110-26-1
1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-N-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

: 1574113-03-3
1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-4-ethyl-N-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: bromine / acetic acid / 10 - 20 °C

2: palladium diacetate; XPhos / toluene / 120 °C

With bromine; palladium diacetate; XPhos; In acetic acid; toluene;

Reference yield:

: 1-chloro-4-(1-iodo-2-tosylethyl)benzene

: 1574113-03-3
1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-4-ethyl-N-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / acetonitrile / 1 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C / Inert atmosphere

2.2: 18 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C / Inert atmosphere; Cooling

3.2: 24 h

4.1: sodium hydroxide; methanol / tetrahydrofuran; water / 18 h / Reflux

5.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

6.1: ferrous(II) sulfate heptahydrate / dimethyl sulfoxide / 0.18 h

7.1: bromine / acetic acid / 10 - 20 °C

8.1: palladium diacetate; XPhos / toluene / 120 °C

With methanol; ferrous(II) sulfate heptahydrate; 1-hydroxy-7-aza-benzotriazole; bromine; palladium diacetate; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; XPhos; In tetrahydrofuran; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;