1-[1-(4-fluorophenyl)-5-isopropoxypyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

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Chemical Name:1-[1-(4-fluorophenyl)-5-isopropoxypyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one
CAS No.:1613395-12-2
Molecular Formula:C₂₁H₂₁F₄N₅O₂
Molecular Weight:451.424
Hs Code.:

Synonyms:1-[1-(4-fluorophenyl)-5-isopropoxypyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

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Chemical Property of 1-[1-(4-fluorophenyl)-5-isopropoxypyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

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Technology Process of 1-[1-(4-fluorophenyl)-5-isopropoxypyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

There total 10 articles about 1-[1-(4-fluorophenyl)-5-isopropoxypyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.4%

: 1613396-01-2
C₂₂H₂₅F₄N₅O₅S

: 1613395-12-2
1-[1-(4-fluorophenyl)-5-isopropoxypyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 60 ℃; for 2h;

Reference yield:

: 1613395-95-1
C₁₂H₁₂FN₃O₃

: 1613395-12-2
1-[1-(4-fluorophenyl)-5-isopropoxypyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: iron; hydrogenchloride / ethanol; water / 0.33 h / 80 °C

2: trimethylaluminum / 1,2-dichloro-ethane; toluene / 2 h / 0 - 20 °C

3: triethylamine / dichloromethane / 2 h / 20 °C

4: sodium hydride / tetrahydrofuran / 2 h / 0 - 60 °C

With hydrogenchloride; trimethylaluminum; iron; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; toluene;

Reference yield:

: 1613395-93-9
5-chloro-1-(4-fluorophenyl)-4-nitro-pyrazole

: 1613395-12-2
1-[1-(4-fluorophenyl)-5-isopropoxypyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / 1-methyl-pyrrolidin-2-one / 3 h / 0 - 100 °C / Inert atmosphere

2: iron; hydrogenchloride / ethanol; water / 0.33 h / 80 °C

3: trimethylaluminum / 1,2-dichloro-ethane; toluene / 2 h / 0 - 20 °C

4: triethylamine / dichloromethane / 2 h / 20 °C

5: sodium hydride / tetrahydrofuran / 2 h / 0 - 60 °C

With hydrogenchloride; trimethylaluminum; iron; sodium hydride; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; 1,2-dichloro-ethane; toluene;