(E)-N-{3-fluoro-4-[4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl]phenyl}cinnamamide

Base Information

Chemical Name:(E)-N-{3-fluoro-4-[4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl]phenyl}cinnamamide
CAS No.:1580002-99-8
Molecular Formula:C₂₇H₂₃F₄N₃O₂
Molecular Weight:497.492
Hs Code.:

Synonyms:(E)-N-{3-fluoro-4-[4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl]phenyl}cinnamamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-N-{3-fluoro-4-[4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl]phenyl}cinnamamide

Chemical Property:

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Technology Process of (E)-N-{3-fluoro-4-[4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl]phenyl}cinnamamide

There total 7 articles about (E)-N-{3-fluoro-4-[4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl]phenyl}cinnamamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.22%

: 1580002-75-0
(E)-N-[3-fluoro-4-(piperazin-1-yl)phenyl]cinnamamide

: 312-94-7
2-trifluoromethylbenzoyl chloride

: 1580002-99-8
(E)-N-{3-fluoro-4-[4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl]phenyl}cinnamamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.01.024

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 1580002-99-8
(E)-N-{3-fluoro-4-[4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl]phenyl}cinnamamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / dimethyl sulfoxide / 12 h / 90 °C

2.1: hydrogen; palladium 10% on activated carbon / ethyl acetate; methanol / 6 h / 5171.62 Torr

3.1: pyridine / dichloromethane / 3 h / 0 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

4.2: 0.17 h

5.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/j.ejmech.2014.01.024

Reference yield:

: 154590-34-8
4-(2-fluoro-4-nitrophenyl)-piperazine-1-carboxylic acid tert butyl ester

: 1580002-99-8
(E)-N-{3-fluoro-4-[4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl]phenyl}cinnamamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; palladium 10% on activated carbon / ethyl acetate; methanol / 6 h / 5171.62 Torr

2.1: pyridine / dichloromethane / 3 h / 0 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

3.2: 0.17 h

4.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.ejmech.2014.01.024