(1S,2R,4R,5S)-2-Azidomethyl-4-p-tolylsulfanyl-3,6-dioxa-bicyclo[3.1.0]hexane

Base Information

• Chemical Name: (1S,2R,4R,5S)-2-Azidomethyl-4-p-tolylsulfanyl-3,6-dioxa-bicyclo[3.1.0]hexane
• CAS No.: 637035-77-9
• Molecular Formula: C₁₂H₁₃N₃O₂S
• Molecular Weight: 263.32
• Mol file: 637035-77-9.mol

Synonyms:(1S,2R,4R,5S)-2-Azidomethyl-4-p-tolylsulfanyl-3,6-dioxa-bicyclo[3.1.0]hexane

Chemical Property of (1S,2R,4R,5S)-2-Azidomethyl-4-p-tolylsulfanyl-3,6-dioxa-bicyclo[3.1.0]hexane

Chemical Property:

Purity/Quality:

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Technology Process of (1S,2R,4R,5S)-2-Azidomethyl-4-p-tolylsulfanyl-3,6-dioxa-bicyclo[3.1.0]hexane

There total 1 articles about (1S,2R,4R,5S)-2-Azidomethyl-4-p-tolylsulfanyl-3,6-dioxa-bicyclo[3.1.0]hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

p-methylphenyl 1-thio-α-D-arabinofuranoside (204918-49-0) → (1S,2R,4R,5S)-2-Azidomethyl-4-p-tolylsulfanyl-3,6-dioxa-bicyclo[3.1.0]hexane (637035-77-9)

Guidance literature:

With di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1055/s-2003-40335

Reference yield: 83.0%

(1S,2R,4R,5S)-2-Azidomethyl-4-p-tolylsulfanyl-3,6-dioxa-bicyclo[3.1.0]hexane (637035-77-9) → (1S,2R,4R,5S)-2-Azidomethyl-4-(toluene-4-sulfinyl)-3,6-dioxa-bicyclo[3.1.0]hexane (637035-73-5)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -78 - 20 ℃;

DOI:10.1055/s-2003-40335

upstream raw materials:

p-methylphenyl 1-thio-α-D-arabinofuranoside

Downstream raw materials:

(1S,2R,4R,5S)-2-Azidomethyl-4-(toluene-4-sulfinyl)-3,6-dioxa-bicyclo[3.1.0]hexane