3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridine-7-carbaldehyde

Base Information

• Chemical Name: 3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridine-7-carbaldehyde
• CAS No.: 1042442-34-1
• Molecular Formula: C₁₈H₁₂FN₅O
• Molecular Weight: 333.325

Synonyms:3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridine-7-carbaldehyde

Chemical Property of 3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridine-7-carbaldehyde

Chemical Property:

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Technology Process of 3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridine-7-carbaldehyde

There total 1 articles about 3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridine-7-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

[3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]methanol (480459-11-8) → 3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridine-7-carbaldehyde (1042442-34-1)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2007.09.013

Reference yield: 58.0%

1-methyl-piperazine (109-01-3) + 3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridine-7-carbaldehyde (1042442-34-1) → C23H24FN7 (480458-99-9)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2007.09.013

Reference yield: 50.0%

3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridine-7-carbaldehyde (1042442-34-1) → 3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridine-7-carbonitrile

Guidance literature:

With hydroxylamine hydrochloride; trifluoroacetic acid; at 85 ℃; for 15h;

DOI:10.1016/j.ejmech.2007.09.013

upstream raw materials:

[3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]methanol

Downstream raw materials:

C₂₃H₂₄FN₇

C₂₁H₂₁FN₆O

C₂₂H₁₉FN₆

C₂₂H₂₃FN₆O

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