Fmoc-4-(tert-butoxycarbonylmethoxy)-L-phenylalanine

Base Information

• Chemical Name: Fmoc-4-(tert-butoxycarbonylmethoxy)-L-phenylalanine
• CAS No.: 181951-92-8
• Molecular Formula: C30H31NO7
• Molecular Weight: 517.57
• Hs Code.: 29225090
• DSSTox Substance ID: DTXSID50373291
• Nikkaji Number: J982.964D
• Wikidata: Q72478900
• Mol file: 181951-92-8.mol

Synonyms:181951-92-8;Fmoc-4-(tert-butoxycarbonylmethoxy)-L-phenylalanine;Fmoc-4-(Boc-methoxy)-L-phenylalanine;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(2-(tert-butoxy)-2-oxoethoxy)phenyl)propanoic acid;(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[4-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]phenyl]propanoic acid;N-Fmoc-4-(tert-butoxycarbonylmethoxy)-L-phenylalanine;C30H31NO7;SCHEMBL2018447;DTXSID50373291;HGZSQWKDOAHSLN-SANMLTNESA-N;MFCD07781259;AKOS015837310;AKOS015907810;HY-W088097;L-Tyrosine, O-[2-(1,1-dimethylethoxy)-2-oxoethyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-;L-Tyrosine,O-[2-(1,1-dimethylethoxy)-2-oxoethyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-;BS-21793;PD197246;CS-0130196;Fmoc-4-(tert-butoxycarbonylmethoxy)-L-Phe-OH;D92923;A880954;N-Fmoc-O-(2-tert-butoxy-2-oxoethyl)-L-tyrosine;N-(9H-Fluorene-9-ylmethoxycarbonyl)-O-(2-oxo-2-tert-butoxyethyl)-L-tyrosine;O-(2-tert-Butoxy-2-oxoethyl)-N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-tyrosine;(2S)-3-{4-[2-(tert-butoxy)-2-oxoethoxy]phenyl}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid;(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-(2-tert-butoxy-2-oxoethoxy)phenyl)propanoic acid

Chemical Property of Fmoc-4-(tert-butoxycarbonylmethoxy)-L-phenylalanine

Chemical Property:

• Boiling Point: 699.6 °C at 760 mmHg
• Flash Point: 376.9 °C
• PSA: 111.16000
• Density: 1.251 g/cm³
• LogP: 5.33240
• Storage Temp.: 2-8°C
• XLogP3: 5.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 12
• Exact Mass: 517.21005233
• Heavy Atom Count: 38
• Complexity: 794

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-4-(tert-butoxycarbonylmethoxy)-l-phenylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)COC1=CC=C(C=C1)CC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
• Isomeric SMILES: CC(C)(C)OC(=O)COC1=CC=C(C=C1)C[C@@H](C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Technology Process of Fmoc-4-(tert-butoxycarbonylmethoxy)-L-phenylalanine

There total 4 articles about Fmoc-4-(tert-butoxycarbonylmethoxy)-L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + (S)-2-Amino-3-(4-tert-butoxycarbonylmethoxy-phenyl)-propionic acid (145544-50-9) → (S)-3-(4-tert-Butoxycarbonylmethoxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid (181951-92-8)

Guidance literature:

With potassium hydrogencarbonate; In 1,4-dioxane; water; Ambient temperature;

DOI:10.1016/S0040-4020(98)00590-0

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → (S)-3-(4-tert-Butoxycarbonylmethoxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid (181951-92-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1) DMF, rt, 40 min; 2) DMF, overnight

2: 91 percent / H₂ / Pd/C / methanol / 2068.6 Torr / Ambient temperature

3: 87 percent / KHCO₃ / dioxane; H₂O / Ambient temperature

With hydrogen; sodium hydride; potassium hydrogencarbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; water;

DOI:10.1016/S0040-4020(98)00590-0

Reference yield:

benzyl N-carbobenzyloxy-L-tyrosine (5513-40-6) → (S)-3-(4-tert-Butoxycarbonylmethoxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid (181951-92-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1) DMF, rt, 40 min; 2) DMF, overnight

2: 91 percent / H₂ / Pd/C / methanol / 2068.6 Torr / Ambient temperature

3: 87 percent / KHCO₃ / dioxane; H₂O / Ambient temperature

With hydrogen; sodium hydride; potassium hydrogencarbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; water;

DOI:10.1016/S0040-4020(98)00590-0

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

(S)-2-Amino-3-(4-tert-butoxycarbonylmethoxy-phenyl)-propionic acid

bromoacetic acid tert-butyl ester

benzyl N-carbobenzyloxy-L-tyrosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 181951-92-8 FMOC-4-(TERT-BUTOXYCARBONYLMETHOXY)-L-PHENYLALANINE

Send

Send

Metric Ton KG G Pound L ML

Send

Send