1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3]triazole-4-carboxylic acid [(R)-cyano-(4-ethyl-phenyl)-methyl]-amide

Base Information

Chemical Name:1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3]triazole-4-carboxylic acid [(R)-cyano-(4-ethyl-phenyl)-methyl]-amide
CAS No.:1613253-11-4
Molecular Formula:C₂₅H₂₈N₆O₅
Molecular Weight:492.535
Hs Code.:

Synonyms:1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3]triazole-4-carboxylic acid [(R)-cyano-(4-ethyl-phenyl)-methyl]-amide

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Chemical Property of 1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3]triazole-4-carboxylic acid [(R)-cyano-(4-ethyl-phenyl)-methyl]-amide

Chemical Property:

Purity/Quality:

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Technology Process of 1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3]triazole-4-carboxylic acid [(R)-cyano-(4-ethyl-phenyl)-methyl]-amide

There total 5 articles about 1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3]triazole-4-carboxylic acid [(R)-cyano-(4-ethyl-phenyl)-methyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613252-63-3
1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3]triazole-4-carboxylic acid [cyano-(4-ethyl-phenyl)-methyl]amide

: 1613253-11-4
1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3]triazole-4-carboxylic acid [(R)-cyano-(4-ethyl-phenyl)-methyl]-amide

: 1613253-12-5
1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3]triazole-4-carboxylic acid [(S)-cyano-(4-ethyl-phenyl)-methyl]-amide

Guidance literature:: With Chiralpak AD; In n-heptane; isopropyl alcohol; Resolution of racemate;

Reference yield:

: 1-(2-amino-ethyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester hydrochloride

: 1613253-11-4
1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3]triazole-4-carboxylic acid [(R)-cyano-(4-ethyl-phenyl)-methyl]-amide

: 1613253-12-5
1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3]triazole-4-carboxylic acid [(S)-cyano-(4-ethyl-phenyl)-methyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 1 h / 0 °C

1.2: 20 °C

2.1: sodium hydroxide; water / methanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 1 h / 0 °C

3.2: 20 °C

4.1: Chiralpak AD / isopropyl alcohol; n-heptane / Resolution of racemate

With water; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In methanol; n-heptane; N,N-dimethyl acetamide; isopropyl alcohol;

Reference yield:

: 1-(2-tert-butoxycarbonylamino-ethyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

: 1613253-11-4
1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3]triazole-4-carboxylic acid [(R)-cyano-(4-ethyl-phenyl)-methyl]-amide

: 1613253-12-5
1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3]triazole-4-carboxylic acid [(S)-cyano-(4-ethyl-phenyl)-methyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 1 h / 0 °C

2.2: 20 °C

3.1: sodium hydroxide; water / methanol / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 1 h / 0 °C

4.2: 20 °C

5.1: Chiralpak AD / isopropyl alcohol; n-heptane / Resolution of racemate

With hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In 1,4-dioxane; methanol; n-heptane; N,N-dimethyl acetamide; isopropyl alcohol;