3-[1-(4-chlorobenzyl)-3-(1,1-dimethylethylthio)-5-(pyrid-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropionic acid

Base Information

• Chemical Name: 3-[1-(4-chlorobenzyl)-3-(1,1-dimethylethylthio)-5-(pyrid-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropionic acid
• CAS No.: 148929-01-5
• Molecular Formula: C₃₀H₃₃ClN₂O₃S
• Molecular Weight: 537.123

Synonyms:3-[1-(4-chlorobenzyl)-3-(1,1-dimethylethylthio)-5-(pyrid-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropionic acid

Chemical Property of 3-[1-(4-chlorobenzyl)-3-(1,1-dimethylethylthio)-5-(pyrid-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropionic acid

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Technology Process of 3-[1-(4-chlorobenzyl)-3-(1,1-dimethylethylthio)-5-(pyrid-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropionic acid

There total 10 articles about 3-[1-(4-chlorobenzyl)-3-(1,1-dimethylethylthio)-5-(pyrid-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloromethylpyridine (4377-33-7) → 3-[1-(4-chlorobenzyl)-3-(1,1-dimethylethylthio)-5-(pyrid-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropionic acid (148929-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Cs₂CO₃ / dimethylformamide; acetonitrile / 4 h / 70 °C

2: aq. LiOH / tetrahydrofuran; methanol / 3 h / Heating

With lithium hydroxide; caesium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0960-894X(99)00399-6

Reference yield:

2-chloromethylpyridine (4377-33-7) → 3-[1-(4-chlorobenzyl)-3-(1,1-dimethylethylthio)-5-(pyrid-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropionic acid (148929-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 96 h / Ambient temperature

2: LiOH / methanol; tetrahydrofuran / 3 h / Heating

With lithium hydroxide; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(96)00271-5

Reference yield:

3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester → 3-[1-(4-chlorobenzyl)-3-(1,1-dimethylethylthio)-5-(pyrid-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropionic acid (148929-01-5)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; for 3h; Heating;

DOI:10.1016/S0960-894X(96)00271-5

upstream raw materials:

methyl 3-[1-(4-chlorobenzyl)-3-(1,1-dimethylethylthio)-5-(pyrid-2-ylmethoxy)-indol-2-yl]-2,2-dimethylpropionate

2-chloromethylpyridine

methyl 3-[1-(4-chlorobenzyl)-3-(1,1-dimethylethylthio)-5-hydroxyindol-2-yl]-2,2-dimethylpropionate

1-(4-chlorobenzyl)-1-(4-methoxyphenyl)hydrazine

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