2-(DIETHYLPHOSPHONYLMETHYL)-5-BROMOPYRIDINE

Base Information

Chemical Name:2-(DIETHYLPHOSPHONYLMETHYL)-5-BROMOPYRIDINE
CAS No.:380893-73-2
Molecular Formula:C10H15 Br N O3 P
Molecular Weight:308.112
Hs Code.:
Mol file:380893-73-2.mol

Synonyms:Phosphonicacid, [(5-bromo-2-pyridinyl)methyl]-, diethyl ester (9CI); Diethyl [(5-bromo-2-pyridyl)methyl]phosphonate

Suppliers and Price of 2-(DIETHYLPHOSPHONYLMETHYL)-5-BROMOPYRIDINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Diethyl((5-bromopyridin-2-yl)methyl)phosphonate 95+%
1g
$ 380.00

American Custom Chemicals Corporation
2-(DIETHYLPHOSPHONYLMETHYL)-5-BROMOPYRIDINE 95.00%
5MG
$ 498.31

Alichem
Diethyl((5-bromopyridin-2-yl)methyl)phosphonate
1g
$ 400.00

Total 17 raw suppliers

Chemical Property of 2-(DIETHYLPHOSPHONYLMETHYL)-5-BROMOPYRIDINE

Chemical Property:

PSA：58.23000
LogP:3.61020

Purity/Quality:

97% ^*data from raw suppliers

Diethyl((5-bromopyridin-2-yl)methyl)phosphonate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(DIETHYLPHOSPHONYLMETHYL)-5-BROMOPYRIDINE

There total 7 articles about 2-(DIETHYLPHOSPHONYLMETHYL)-5-BROMOPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 380893-61-8
(5-bromopyridin-2-yl)methyl methanesulfonate

: 762-04-9
phosphonic acid diethyl ester

: 380893-73-2
[(5-bromo-2-pyridinyl)methyl]-phosphonic acid diethyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/jm070704k

Reference yield:

: 168823-76-5
5-bromo-2-(chloromethyl)pyridine

: 380893-73-2
[(5-bromo-2-pyridinyl)methyl]-phosphonic acid diethyl ester

Guidance literature:: phosphonic acid diethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at 25 ℃; for 1h;

5-bromo-2-(chloromethyl)pyridine; In tetrahydrofuran; toluene; at 25 ℃; for 3h;

With sodium chloride; In tetrahydrofuran; water; toluene;

Reference yield:

: 3430-13-5
5-bromo-2-methylpyridine

: 380893-73-2
[(5-bromo-2-pyridinyl)methyl]-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 5 h

2.1: acetic anhydride / 12 h / 90 °C

2.2: 0 - 20 °C

3.1: thionyl chloride / dichloromethane / 0 - 20 °C

4.1: 120 °C / Inert atmosphere

With thionyl chloride; acetic anhydride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform; 4.1: Arbuzov reaction;
DOI:10.1021/jm200363d