(3S)-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

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Chemical Name:(3S)-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid
CAS No.:1541197-33-4
Molecular Formula:C₂₈H₃₁ClN₆O₇
Molecular Weight:599.043
Hs Code.:

(3S)-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Synonyms:(3S)-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

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Chemical Property of (3S)-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

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Technology Process of (3S)-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

There total 14 articles about (3S)-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1541199-31-8
(3S)-ethyl 3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

: 1541197-33-4
(3S)-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Guidance literature:: With lithium hydroxide monohydrate; In water; acetonitrile; at 20 ℃;

Reference yield:

: 1541198-29-1
C₁₅H₁₈ClNO₄

: 1541197-33-4
(3S)-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic anhydride; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / acetone / 14 h / 20 °C / Inert atmosphere

3.1: ammonium acetate / ethanol / 7 h / Heating

4.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 120 h / 20 °C / pH 8.32 / Enzymatic reaction

4.2: 0.25 h / 20 °C

5.1: hydrogenchloride / 6 h / Reflux; Inert atmosphere

6.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

6.2: 20 °C / Inert atmosphere

7.1: lithium hydroxide monohydrate / acetonitrile; water / 20 °C

With hydrogenchloride; potassium dihydrogenphosphate; Amano Lipase PS; lithium hydroxide monohydrate; ammonium acetate; benzotriazol-1-ol; toluene-4-sulfonic acid; triethylamine; trifluoroacetic anhydride; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 1541198-30-4
C₁₅H₁₆ClNO₃

: 1541197-33-4
(3S)-3-(3-chloro-5-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / acetone / 14 h / 20 °C / Inert atmosphere

2.1: ammonium acetate / ethanol / 7 h / Heating

3.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 120 h / 20 °C / pH 8.32 / Enzymatic reaction

3.2: 0.25 h / 20 °C

4.1: hydrogenchloride / 6 h / Reflux; Inert atmosphere

5.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

6.1: lithium hydroxide monohydrate / acetonitrile; water / 20 °C

With hydrogenchloride; potassium dihydrogenphosphate; Amano Lipase PS; lithium hydroxide monohydrate; ammonium acetate; benzotriazol-1-ol; toluene-4-sulfonic acid; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;