3,3-dimethyl-1-[4-methyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-yl]butan-2-ol

Base Information

Chemical Name:3,3-dimethyl-1-[4-methyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-yl]butan-2-ol
CAS No.:626606-02-8
Molecular Formula:C₂₁H₂₅N₃O₃
Molecular Weight:367.448
Hs Code.:

Synonyms:3,3-dimethyl-1-[4-methyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-yl]butan-2-ol

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Chemical Property of 3,3-dimethyl-1-[4-methyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-yl]butan-2-ol

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Technology Process of 3,3-dimethyl-1-[4-methyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-yl]butan-2-ol

There total 3 articles about 3,3-dimethyl-1-[4-methyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-yl]butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 2245-30-9,40102-55-4,41796-67-2,62137-90-0
1,2-epoxy-3,3-dimethylbutane

: 626606-15-3
4-methyl-2-(3-methyl-2-nitrophenyl)-1H-benzimidazole

: 626606-02-8
3,3-dimethyl-1-[4-methyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-yl]butan-2-ol

Guidance literature:: copper(II) bis(trifluoromethanesulfonate); In acetonitrile; for 19h; Heating;
DOI:10.1021/ol035761w

Reference yield:

: 5437-38-7
3-methyl-2-nitrobenzoic acid

: 626606-02-8
3,3-dimethyl-1-[4-methyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-yl]butan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl chloride; DMF / CH₂Cl₂ / 3 h

2.1: Et₃N / CH₂Cl₂ / 4.5 h / 0 - 20 °C

2.2: 89 percent / AcOH; AcONa / 17 h / Heating

3.1: 39 percent / Cu(OTf)2 / acetonitrile / 19 h / Heating

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; acetonitrile;
DOI:10.1021/ol035761w

Reference yield:

: 50424-93-6
3-methyl-2-nitrobenzoyl chloride

: 626606-02-8
3,3-dimethyl-1-[4-methyl-2-(3-methyl-2-nitrophenyl)benzimidazol-1-yl]butan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N / CH₂Cl₂ / 4.5 h / 0 - 20 °C

1.2: 89 percent / AcOH; AcONa / 17 h / Heating

2.1: 39 percent / Cu(OTf)2 / acetonitrile / 19 h / Heating

With triethylamine; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; acetonitrile;
DOI:10.1021/ol035761w