1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N′-(2-hydroxybenzyl),N′-(4-methylbenzyl)amino]propan-2-ol

Base Information

• Chemical Name: 1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N′-(2-hydroxybenzyl),N′-(4-methylbenzyl)amino]propan-2-ol
• CAS No.: 1401696-19-2
• Molecular Formula: C₃₁H₃₅N₃O₃
• Molecular Weight: 497.637
• Mol file: 1401696-19-2.mol

Synonyms:1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N′-(2-hydroxybenzyl),N′-(4-methylbenzyl)amino]propan-2-ol

Chemical Property of 1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N′-(2-hydroxybenzyl),N′-(4-methylbenzyl)amino]propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N′-(2-hydroxybenzyl),N′-(4-methylbenzyl)amino]propan-2-ol

There total 9 articles about 1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N′-(2-hydroxybenzyl),N′-(4-methylbenzyl)amino]propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

2-{[(3-chloro-2-hydroxypropyl)[(4-methylphenyl)methyl]amino]methyl}phenol (1401696-29-4) + N-(2-pyridylmethyl)-2-hydroxybenzylamine (63671-68-1) → 1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N′-(2-hydroxybenzyl),N′-(4-methylbenzyl)amino]propan-2-ol (1401696-19-2)

Guidance literature:

With triethylamine; potassium iodide; In tetrahydrofuran; for 72h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2012.08.057

Reference yield:

C24H29N3O2 (1401696-41-0) + salicylaldehyde (90-02-8) → 1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N′-(2-hydroxybenzyl),N′-(4-methylbenzyl)amino]propan-2-ol (1401696-19-2)

Guidance literature:

C₂₄H₂₉N₃O₂; salicylaldehyde; In methanol; Reflux;

With sodium tris(acetoxy)borohydride; In methanol; dichloromethane; at 20 ℃; Reflux;

DOI:10.1016/j.tetlet.2012.08.057

Reference yield:

salicylaldehyde (90-02-8) → 1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N′-(2-hydroxybenzyl),N′-(4-methylbenzyl)amino]propan-2-ol (1401696-19-2)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / Reflux

2: sodium tetrahydroborate / ethanol / 2 h / 0 - 80 °C

3: triethylamine; potassium iodide / tetrahydrofuran / 72 h / Inert atmosphere; Reflux

With sodium tetrahydroborate; triethylamine; potassium iodide; In tetrahydrofuran; ethanol;

DOI:10.1016/j.tetlet.2012.08.057

upstream raw materials:

2-({[(4-methylphenyl)methyl](oxiran-2-ylmethyl)amino}methyl)phenol

salicylaldehyde

C₂₄H₂₉N₃O₂

2-((pyridin-2-ylmethylimino)methyl)phenol